Department of Dermatology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
Br J Dermatol. 2014 Apr;170(4):858-65. doi: 10.1111/bjd.12807.
Results of profilometric skin analyses after fractional ablative skin resurfacing are not only important for evaluating the efficacy of this therapy but are also relevant for physicians practising laser and aesthetic skin therapy. Currently, objective measurements of wrinkle reduction after fractional CO2 laser resurfacing are scarce, and it remains unclear whether the various facial areas respond differently to this therapy.
To measure wrinkle parameters, the homogeneity of melanin distribution and skin roughness in four facial areas (periorbital, perioral, forehead, cheeks) before and after three fractional CO2 laser treatments.
Twenty-five women were analysed with regard to wrinkle parameters and mottled pigmentation on the face. We measured wrinkle size, depth and width and the homogeneity of melanin distribution and skin roughness in four facial areas before and after three fractional CO2 laser treatments. Additionally, the investigators rated clinical improvement using five-point grading scales.
Wrinkles were significantly reduced in all facial areas, and the best results for wrinkle size and depth were found for the cheeks (-58·3%, P = 0·018 and -51·3%, P = 0·018) and the periorbital area (-35·1%, P < 0·001 and -31·1%, P = 0·001, respectively). The percentage improvements of rhytides evaluated by the investigators were mostly similar to those found from in vivo measurements. The homogeneity of melanin distribution in the skin was improved by 21·4% on the cheeks (P = 0·012) and by 24·0% in the periorbital area (P < 0·001). Clinical investigators rated the improvement of mottled pigmentation considerably higher (51-75%).
After a serial treatment with the fractional CO2 laser, we measured considerably varying wrinkle reduction depending on the area of the face, and the best results were found for the cheeks.
点阵式消融皮肤换肤术治疗后的轮廓分析结果不仅对评估该疗法的疗效很重要，对从事激光和美容皮肤治疗的医生也很重要。目前，点阵 CO2 激光换肤术后皱纹减少的客观测量数据很少，而且尚不清楚各个面部区域对这种治疗的反应是否不同。
测量四个面部区域（眶周、口周、额部、颊部）三次点阵 CO2 激光治疗前后皱纹参数、黑素分布均匀度和皮肤粗糙度。
分析 25 名女性的面部皱纹参数和斑驳色素沉着情况。我们在三次点阵 CO2 激光治疗前后测量了四个面部区域的皱纹大小、深度和宽度，黑素分布均匀度和皮肤粗糙度，并使用五分制评分标准评估临床改善情况。
所有面部区域的皱纹均显著减少，脸颊和眶周区域的皱纹大小和深度改善最明显（-58.3%，P=0.018 和-51.3%，P=0.018）。调查员评估的皱纹改善百分比与体内测量结果大多相似。皮肤黑素分布均匀度在颊部改善了 21.4%（P=0.012），眶周区域改善了 24.0%（P<0.001）。临床调查员对斑驳色素沉着的改善评价更高（51%-75%）。
经过点阵 CO2 激光的连续治疗，我们根据面部区域测量到了不同程度的皱纹减少，并且颊部的效果最好。
