Institute of Anatomy and Cell Biology, University of Freiburg, Albertstraße 17, 79104 Freiburg, Germany.
Curr Med Chem. 2014;21(19):2190-207. doi: 10.2174/0929867321666131227162215.
The vascular system distributes oxygen and nutrients to all tissues in the body. Additionally, the vascular system also functions in hosting and instructing tissue-specific stem and progenitor cells. Both cell- or blood-derived signals from the vascular system regulate stem cell properties in health and disease. Studies in animal models and in human disease have begun to uncover that signals from the vascular system are not merely maintaining the stem cell niche, but also instruct stem cells for repair mechanisms outside their niche. The present article focuses on recent findings about cell- or blood-derived factors in the vascular system supporting stem cell niche maintenance or activation for tissue homeostasis and repair. We highlight the fact that certain aspects of vascular - stem cell communication are conserved between stem cell niches in different tissues. Within this context, we will especially emphasize on a potential role of the altered vascular system after CNS disease in instructing stem cell fate. Understanding the communication between the vascular system and neural stem cells might support the development for new therapeutic approaches for CNS disease.
血管系统将氧气和营养物质分配到全身的所有组织中。此外，血管系统还具有容纳和指导组织特异性干细胞和祖细胞的功能。来自血管系统的细胞或血液衍生信号在健康和疾病中调节干细胞特性。动物模型和人类疾病的研究已经开始揭示，来自血管系统的信号不仅维持干细胞龛位，而且还为龛位外的修复机制指导干细胞。本文重点介绍了关于血管系统中细胞或血液衍生因子的最新发现，这些因子支持干细胞龛位维持或激活，以维持组织内稳态和修复。我们强调了这样一个事实，即不同组织中的干细胞龛位之间，血管-干细胞通讯的某些方面是保守的。在这种情况下，我们将特别强调中枢神经系统疾病后改变的血管系统在指导干细胞命运方面的潜在作用。了解血管系统与神经干细胞之间的通讯可能有助于为中枢神经系统疾病开发新的治疗方法。
