Infectious Diseases Service, University of Caxias do Sul - Hospital de Geral. 255 Prof Antonio Vignolli St, Caxias do Sul, 95070-561, Brazil.
Curr Pharm Biotechnol. 2013;14(11):951-9. doi: 10.2174/1389201014666131226143923.
Pseudomonas aeruginosa is one of the major pathogens responsible for a wide variety of severe nosocomial and community acquired infections. Numerous vaccine candidates and several monoclonal antibodies have been developed over the past 40 years but only a few have reached clinical trials and none of these vaccine candidates has obtained market authorization. The understanding of P. aeruginosa pathogenesis and its virulence factors is essential in the identification of immunogens that can be used for a P. aeruginosa vaccine. This review summarizes the present status of vaccine development for this important pathogen.
铜绿假单胞菌是引起多种严重医院获得性和社区获得性感染的主要病原体之一。在过去的 40 年中，已经开发了许多疫苗候选物和几种单克隆抗体，但只有少数进入临床试验，而且这些疫苗候选物都没有获得市场授权。了解铜绿假单胞菌的发病机制及其毒力因子对于确定可用于铜绿假单胞菌疫苗的免疫原至关重要。本文综述了该重要病原体疫苗开发的现状。
