De Berardis Domenico, Fornaro Michele, Serroni Nicola, Marini Stefano, Piersanti Monica, Cavuto Marilde, Valchera Alessandro, Mazza Monica, Girinelli Gabriella, Iasevoli Felice, Perna Giampaolo, Martinotti Giovanni, Di Giannantonio Massimo
Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4, p.zza Italia 1, 64100 Teramo, Italy.
Recent Pat Endocr Metab Immune Drug Discov. 2014 Jan;8(1):30-7. doi: 10.2174/1872214807666131229125700.
Hyperprolactinemia is an unwanted adverse effect present in several typical and atypical antipsychotics. Aripiprazole is a drug with partial agonist activity at the level of dopamine receptors D2, which may be effective for antipsychotic- induced hyperprolactinemia. Therefore, we analyzed the literature concerning the treatment of antipsychoticinduced hyperprolactinemia with aripiprazole by updating a previous paper written on the same topic. More recent studies were reviewed. They showed that there are two options for the treatment of antipsychotic-induced hyperprolactinemia with aripiprazole. The safest strategy may require the addition of aripiprazole to ongoing treatments, in the case patients had previously responded to antipsychotic drugs and then developed hyperprolactinemia. However, it is advisable to monitor the patients in case relapses and/or side effect, although rare, might occur. Switching drugs should be considered when a patient does not appear to be responding to the previous antipsychotic, thus developing hyperprolactinemia. A cross-taper switch should always be considered, but the risk of a relapse in the disorder may occur more frequently and the patients should be closely monitored. However, limitations must be considered and further studies are needed to definitely elucidate this important issue. Some relevant patents are also described in this review.
高催乳素血症是几种典型和非典型抗精神病药物存在的不良副作用。阿立哌唑是一种在多巴胺D2受体水平具有部分激动剂活性的药物，可能对抗精神病药物引起的高催乳素血症有效。因此，我们通过更新之前关于同一主题的论文，分析了有关用阿立哌唑治疗抗精神病药物引起的高催乳素血症的文献。对更新的研究进行了综述。结果显示，用阿立哌唑治疗抗精神病药物引起的高催乳素血症有两种选择。最安全的策略可能是在患者先前对抗精神病药物有反应而后出现高催乳素血症的情况下，将阿立哌唑添加到正在进行的治疗中。然而，尽管复发和/或副作用很少见，但仍建议对患者进行监测。当患者似乎对先前的抗精神病药物无反应从而出现高催乳素血症时，应考虑换药。应始终考虑交叉递减换药，但疾病复发的风险可能更频繁出现，患者应密切监测。然而，必须考虑到局限性，还需要进一步研究来明确阐明这一重要问题。本综述还描述了一些相关专利。
