Shah Parag K, Narendran Venkatapathy, Kalpana Narendran
a Department of Pediatric Retina & Ocular Oncology , Aravind Eye Hospital & Postgraduate Institute of Ophthalmology , Coimbatore , Tamilnadu , India.
Ophthalmic Genet. 2015;36(3):248-50. doi: 10.3109/13816810.2013.867450.
To report treatment outcomes of intra- and extraocular retinoblastomas seen at Aravind Eye Hospital, Coimbatore, South India.
Retrospective case series from January 2006 to December 2011 involving 106 babies. Clinical records were reviewed and data collected on presenting signs, gender, age, family history, ocular findings and treatment outcomes. All eyes were classified using the International Retinoblastoma Classification.
The mean follow up was 35.4 months (range 1-75 months, SD 20.2, median 33 months). The mean age of presentation was 20.8 months (range 5 days to 120 months). There were 68 unilateral and 38 bilateral cases. Globe salvage rates were 100% for group A (11 eyes), B (16 eyes) and C (2 eyes). For group D, eye salvage rate was 29.5% (10/34 eyes). Survival rate of orbital retinoblastoma in our study was 55.5% (5/9 cases) at a mean follow up of 33.6 months. The overall patient survival rate was 89.6% with 11 deaths (10.4%). The commonest cause of death (7/11) was distant metastasis due to refusal to take initial treatment.
Greater improvement in patient survival can be achieved not only by early treatment of intraocular disease but also to convince patients to accept treatments including enucleation in this part of the world.
报告印度南部哥印拜陀市阿拉文眼科医院收治的眼内和眶内视网膜母细胞瘤的治疗结果。
回顾性病例系列研究，纳入2006年1月至2011年12月期间的106例婴儿。查阅临床记录，收集关于就诊体征、性别、年龄、家族史、眼部检查结果及治疗结果的数据。所有患眼均按照国际视网膜母细胞瘤分类标准进行分类。
平均随访时间为35.4个月（范围1 - 75个月，标准差20.2，中位数33个月）。平均就诊年龄为20.8个月（范围5天至120个月）。其中单眼病例68例，双眼病例38例。A组（11只眼）、B组（16只眼）和C组（2只眼）的眼球保留率为100%。D组的眼球保留率为29.5%（34只眼中10只）。在本研究中，眶内视网膜母细胞瘤患者在平均33.6个月的随访期内生存率为55.5%（9例中5例）。患者总生存率为89.6%，11例死亡（10.4%）。最常见的死亡原因（11例中有7例）是因拒绝接受初始治疗导致远处转移。
不仅通过早期治疗眼内疾病，而且通过说服患者接受包括眼球摘除术在内的治疗方法，可在世界这一地区实现患者生存率的更大提高。
