印度西部古吉拉特邦人群口腔癌和宫颈癌中高危人乳头瘤病毒16型和18型的流行情况
Prevalence of high-risk human papillomavirus type 16 and 18 in oral and cervical cancers in population from Gujarat, West India.
作者信息
Patel Kinjal R, Vajaria Bhairavi N, Begum Rasheedunnisa, Desai Ava, Patel Jayendra B, Shah Franky D, Shukla Shilin N, Patel Prabhudas S
机构信息
Biochemistry Research Division, The Gujarat Cancer & Research Institute, Ahmedabad, India.
出版信息
J Oral Pathol Med. 2014 Apr;43(4):293-7. doi: 10.1111/jop.12147. Epub 2013 Dec 30.
BACKGROUND
Oral and cervical cancers are major malignancies in men and women, respectively, in India. This study evaluated occurrence of human papillomavirus (HPV) 16 and 18 infections in oral and cervical cancers to estimate HPV-associated burden of these cancers in the population from Gujarat, West India.
METHODS
A total of 97 malignant oral carcinoma tissues and 52 cervical carcinoma tissues were analyzed by type-specific PCR for the presence of HPV type 16 and 18 infections.
RESULTS
None of the oral cancer patients revealed the presence of HPV type 16 and 18 infection. In cervical cancer, 31 (59.6%) patients were infected with HPV 16 and 18. Of these 31 HPV-positive cervical cancer patients, 28 (90.3%) were infected with HPV 16 and 3 (9.7%) were infected with HPV 18.
CONCLUSION
The results suggested that HPV 16 and 18 do not play an important role in oral carcinogenesis in the population from Gujarat, West India. However, HPV 16 is highly prevalent in the cervical cancer patients, which may be considered for planning of prevention programs such as screening and vaccination in women from this region.
背景
在印度，口腔癌和宫颈癌分别是男性和女性中的主要恶性肿瘤。本研究评估了口腔癌和宫颈癌中人类乳头瘤病毒（HPV）16型和18型感染的发生率，以估计印度西部古吉拉特邦人群中这些癌症与HPV相关的负担。
方法
通过型特异性PCR分析了总共97例口腔恶性癌组织和52例宫颈癌组织，以检测HPV 16型和18型感染的存在情况。
结果
口腔癌患者中均未发现HPV 16型和18型感染。在宫颈癌患者中，31例（59.6%）感染了HPV 16和18。在这31例HPV阳性的宫颈癌患者中，28例（90.3%）感染了HPV 16，3例（9.7%）感染了HPV 18。
结论
结果表明，HPV 16和18在印度西部古吉拉特邦人群的口腔癌发生过程中不起重要作用。然而，HPV 16在宫颈癌患者中高度流行，这在为该地区女性制定筛查和疫苗接种等预防计划时可能需要考虑。
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