Krüger M, Pabst A M, Walter C, Sagheb K, Günther C, Blatt S, Weise K, Al-Nawas B, Ziebart T
Department of Oral and Maxillofacial Surgery - Plastic Surgery (Head: Univ. Prof. Dr. Dr. W. Wagner), University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.
Department of Oral and Maxillofacial Surgery - Plastic Surgery (Head: Univ. Prof. Dr. Dr. W. Wagner), University Medical Center of the Johannes Gutenberg-University Mainz, Augustusplatz 2, 55131 Mainz, Germany.
J Craniomaxillofac Surg. 2014 Oct;42(7):1506-14. doi: 10.1016/j.jcms.2014.04.022. Epub 2014 May 10.
In addition to tobacco and alcohol consumption, the two main risk factors for oral squamous cell carcinoma (OSCC), recent studies have revealed infections with human papilloma virus (HPV) as an additional risk factor for OSCC development. In the field of head and neck malignancies, the prevalence of HPV infections in oropharyngeal cancer (OC) ranges in different studies up to 84%. While HPV infection is discussed as an independent risk factor in this region, its distinguished role in carcinogenesis of tumours localized to the oral cavity remains still uncertain. In this study, we analysed the HPV status in 88 consecutive patients with OSCCs localized anterior of the palatoglossal arch who were treated in the Department of Oral and Maxillofacial Surgery at the University Medical Center Mainz. The HPV status analysis was performed using DNA-PCR and immunostaining of p16 protein. The prevalence of HPV-positive OSCCs was about 6% (5 patients). In 3 patients the HPV subtypes 16/18 were found. No significant differences between the HPV positive and negative patients regarding age, gender, smoking and alcohol consumption, localization and TNM level could be detected. Contrary to other studies focussing on cancers of the lingual and palatine tonsil, the prevalence of HPV infections was much lower in the oral cavity. Therefore HPV infection might play a less important role in oral carcinogenesis.
除了烟草和酒精消费这两种口腔鳞状细胞癌（OSCC）的主要危险因素外，最近的研究表明，人乳头瘤病毒（HPV）感染是OSCC发生的另一个危险因素。在头颈部恶性肿瘤领域，不同研究中口咽癌（OC）中HPV感染的患病率高达84%。虽然HPV感染在该区域被视为独立危险因素，但其在口腔局部肿瘤发生中的独特作用仍不确定。在本研究中，我们分析了88例连续的OSCC患者的HPV状态，这些患者的肿瘤位于腭舌弓前方，在美因茨大学医学中心口腔颌面外科接受治疗。HPV状态分析采用DNA-PCR和p16蛋白免疫染色进行。HPV阳性的OSCC患病率约为6%（5例患者）。在3例患者中发现了HPV 16/18亚型。在年龄、性别、吸烟和饮酒、肿瘤部位以及TNM分期方面，未检测到HPV阳性和阴性患者之间存在显著差异。与其他聚焦于舌扁桃体和腭扁桃体癌的研究相反，口腔中HPV感染的患病率要低得多。因此，HPV感染在口腔致癌过程中可能起的作用较小。
