Lin Xue-mei, Deng Qi, Zhao Ming-feng, Geng Li, Li Yu-ming
Department of Hematology, First Central Hospital of Tianjin, Tianjin 300192, China.
Department of Hematology, First Central Hospital of Tianjin, Tianjin 300192, China. Email:
Zhonghua Yi Xue Za Zhi. 2013 Sep 24;93(36):2876-9.
To explore the epidemiological profiles of invasive fungal disease (IFD) in hospitalized patients with hematological diseases during 2007-2012.
A total of 419 IFD patients with hematological diseases from January 2007 to December 2012 were reviewed. All of them were analyzed with regards to diagnostic levels, infection sites and various related factors.
(1) A total of 233 cases (55.61%) were preliminarily identified as IFD, 140 cases (33.41%) had a clinical diagnosis and 46 cases (10.98%) were confirmed cases of IFD. (2) Among 46 confirmed cases of IFD, there were agranulocytosis (n = 43) and aspergillosis infection (n = 36). (3) Respiratory tract was the most frequent infection site in all IFD patients (85.20%) . (4) And chemotherapy-induced agranulocytosis was a major reason for IFD patients with hematological diseases. The number of IFD patients without chemotherapy had a rising trend. (5) The age group of IFD was during 41-60 years old. (6) All of them stayed on antibiotic therapy at the diagnosis of IFD. The numbers of antibiotics were two(205 cases, 48.93%) and three(179 cases, 42.72%). (7) The peak incidence of IFD was recorded in January, July and December. And June was another lower peak.
Agranulocytosis is the main reason for IFD patients with hematological disease. The data is important and valuable for the early diagnosis and therapy of IFD patients with hematological disease.
探讨2007 - 2012年期间住院血液病患者侵袭性真菌病（IFD）的流行病学特征。
回顾性分析2007年1月至2012年12月期间共419例血液病IFD患者。对所有患者的诊断水平、感染部位及各种相关因素进行分析。
（1）共233例（55.61%）初步诊断为IFD，140例（33.41%）为临床诊断，46例（10.98%）为确诊病例。（2）在46例确诊的IFD病例中，有粒细胞缺乏症（n = 43）和曲霉感染（n = 36）。（3）呼吸道是所有IFD患者中最常见的感染部位（85.20%）。（4）化疗引起的粒细胞缺乏症是血液病IFD患者的主要原因。未接受化疗的IFD患者数量呈上升趋势。（5）IFD患者的年龄组在41 - 60岁之间。（6）所有患者在诊断为IFD时均接受抗生素治疗。使用两种抗生素的有205例（48.93%），使用三种抗生素的有179例（42.72%）。（7）IFD的发病高峰出现在1月、7月和12月。6月是另一个较低的高峰。
粒细胞缺乏症是血液病IFD患者的主要原因。这些数据对血液病IFD患者的早期诊断和治疗具有重要价值。
