脑室内注射腺激肽释放酶的大鼠中高血压反应与脑激肽水平的关系

Relationship between hypertensive response and brain kinin level in the rat injected intraventricularly with glandular kallikrein.

作者信息

Kariya K, Yamauchi A

出版信息

Jpn J Pharmacol. 1987 Feb;43(2):129-32. doi: 10.1254/jjp.43.129.

DOI:10.1254/jjp.43.129

Abstract

Hypertensive action was observed in conscious rats injected intraventricularly with glandular kallikrein (EC 3.4.21.35) in a dose-dependent manner (4-16 KU), which was associated with the enhancement of brain kinin level. Concurrently administered aprotinin, a kallikrein inhibitor, led to an inhibition of these effects of kallikrein. These results suggest that the central hypertensive action of kallikrein is mediated via the kinin liberated from a kininogen in the brain.

摘要

给清醒大鼠脑室内注射腺体激肽释放酶（EC 3.4.21.35）后，观察到其血压升高作用呈剂量依赖性（4 - 16 KU），这与脑内激肽水平升高有关。同时给予激肽释放酶抑制剂抑肽酶，可抑制激肽释放酶的这些作用。这些结果表明，激肽释放酶的中枢性升压作用是通过脑内激肽原释放的激肽介导的。