Department of Clinical Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue #340, Memphis, TN 38163, USA.
Department of Clinical Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue #340, Memphis, TN 38163, USA.
Int J Antimicrob Agents. 2014 Mar;43(3):279-83. doi: 10.1016/j.ijantimicag.2013.10.025. Epub 2013 Dec 1.
The 2009 novel H1N1 influenza A virus (H1N1) became a global pandemic. Data on antiviral prescriptions by location from 2008 to 2010 have not been reported. The purpose of this study was to assess antiviral geographic trends and correlation with influenza-like illness (ILI) over 3 years. Percent of outpatient ILI visits and antiviral prescriptions from 1 January 2008 to 31 December 2010 were included. Linear regression was used to assess correlation. In total, 14 million antivirals were dispensed during this period. A 115% increase was observed in 2009 compared with prescriptions dispensed in 2008, and an 84% decrease was observed in 2010 compared with 2009. The rate of antivirals was 1.32 prescriptions/100 persons in 2008, 2.85/100 persons in 2009 and 0.435/100 persons in 2010. 2009 regional growth was observed in most states and was highest in the West (293%) and the Northeast (272%). A positive correlation was observed between antivirals and ILI visits (R(2)=0.7853; P<0.0001). With the 2009 H1N1 pandemic, antivirals increased compared with 2008 or 2010. Without the concern of H1N1, antivirals decreased in 2010 to levels lower than 2008. Geographic trends were also observed, which may be a result of the different intensity of influenza transmission and difference practice patterns. ILI diagnoses correlate with influenza antiviral prescription use in the USA.
2009 年新型 H1N1 流感病毒（H1N1）引发了一场全球大流行。目前尚未报告 2008 年至 2010 年各地的抗病毒处方数据。本研究旨在评估 3 年来抗病毒药物的地域趋势及其与流感样疾病（ILI）的相关性。纳入 2008 年 1 月 1 日至 2010 年 12 月 31 日期间的门诊 ILI 就诊百分比和抗病毒处方数据。采用线性回归评估相关性。在此期间共配发了 1400 万份抗病毒药物。与 2008 年相比，2009 年的处方量增加了 115%，而与 2009 年相比，2010 年减少了 84%。2008 年的抗病毒药物配发率为每 100 人 1.32 份处方，2009 年为每 100 人 2.85 份处方，2010 年为每 100 人 0.435 份处方。大多数州的 2009 年均出现了区域增长，增幅最高的是西部（293%）和东北部（272%）。抗病毒药物与 ILI 就诊率呈正相关（R2=0.7853；P<0.0001）。与 2008 年或 2010 年相比，2009 年 H1N1 大流行期间的抗病毒药物用量有所增加。由于不再担心 H1N1，2010 年的抗病毒药物用量下降到了 2008 年以下的水平。还观察到了地域趋势，这可能是由于流感传播的强度不同和实践模式的差异所致。ILI 诊断与美国流感抗病毒药物处方使用相关。
