Williams Laurina O, Kupka Nancy J, Schmaltz Stephen P, Barrett Stacey, Uyeki Timothy M, Jernigan Daniel B
Centre for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G-25, Atlanta, GA 30333, United States.
Department of Health Services Research, Division of Healthcare Quality Evaluation, The Joint Commission, One Rennaisance Boulevard, Oakbrook Terrace, IL 60181, United States.
J Clin Virol. 2014 May;60(1):27-33. doi: 10.1016/j.jcv.2014.01.016. Epub 2014 Feb 12.
Rapid influenza diagnostic tests (RIDTs) can be used at the point-of-care and are often the only influenza tests readily available in outpatient facilities.
To determine the use of RIDTs and antiviral prescription practices in outpatient facilities.
Surveys were mailed to U.S. physician's offices, emergency departments, and community health centers in 2008 (pre-2009 H1N1 pandemic) and 2010 (post-2009 H1N1 pandemic). The 2010 survey included questions to evaluate changes in testing and treatment practices among various risk groups subsequent to the 2009 H1N1 pandemic.
In both surveys, respondents using RIDTs relied on RIDT results to guide prescribing antiviral medications. Greater than two-thirds of these respondents reported prescribing antiviral medications both pre- and post-pandemic for patients within 48h of onset of flu-like symptoms with a positive RIDT (69% pre-pandemic; 67% post-pandemic). After the pandemic (2010 survey), outpatient providers also reported prescribing antivirals to those with flu-like symptoms for 31% of children <2 years, 23% of children 2-5 years, 37% of pregnant patients, and 74% of other patients at high risk; while these figures were higher than pre-pandemic, they represent a failure to use CDC guidelines to prescribe antivirals for patients with suspected influenza who are at higher risk for complications.
Clinicians in outpatient facilities often relied on RIDT findings to aid in making antiviral treatment decisions; however their treatment practices were not always consistent with CDC guidelines. The use of RIDTs and antiviral medicines were influenced by the 2009 H1N1 pandemic.
快速流感诊断检测(RIDTs)可在现场即时使用,且往往是门诊机构中唯一容易获得的流感检测手段。
确定门诊机构中RIDTs的使用情况以及抗病毒药物的处方开具情况。
分别在2008年(2009年甲型H1N1流感大流行前)和2010年(2009年甲型H1N1流感大流行后)向美国的医生办公室、急诊科和社区健康中心邮寄调查问卷。2010年的调查包含一些问题,以评估2009年甲型H1N1流感大流行后不同风险群体在检测和治疗方法上的变化。
在两项调查中,使用RIDTs的受访者都依靠检测结果来指导抗病毒药物的处方开具。超过三分之二的受访者报告称,在大流行前和大流行后,对于出现流感样症状且RIDT检测呈阳性的患者,在发病48小时内均开具了抗病毒药物(大流行前为69%;大流行后为67%)。大流行后(2010年调查),门诊医疗服务提供者还报告称,为出现流感样症状的以下人群开具了抗病毒药物:2岁以下儿童中的31%、2至5岁儿童中的23%、孕妇中的37%以及其他高危患者中的74%;虽然这些数字高于大流行前,但这表明在为疑似流感且并发症风险较高的患者开具抗病毒药物时未遵循美国疾病控制与预防中心(CDC)的指南。
门诊机构的临床医生常常依靠RIDT检测结果来辅助做出抗病毒治疗决策;然而,他们的治疗方法并不总是符合CDC的指南。RIDTs和抗病毒药物的使用受到了2009年甲型H1N1流感大流行的影响。