Laboratory of Tissue Biology and Therapeutic Engineering, Centre National de la Recherche Scientifique (CNRS) UMR 5305, Lyon, France; University of Lyon 1, UMR 5305, Lyon, France.
Ageing Res Rev. 2014 Jan;13:90-9. doi: 10.1016/j.arr.2013.12.003. Epub 2013 Dec 26.
With advancing age, a decline in the main sensory modalities including touch sensation and perception is well reported to occur. This review mainly outlines the peripheral components of touch perception highlighting ageing influences on morphological and functional features of cutaneous mechanical transducers and mechanosensitive ion channels, sensory innervation, neurotransmitters and even vascular system required to ensure efferent function of the afferent nerve fibres in the skin. This, in conjunction with effect of ageing on the skin per se and central nervous system, could explain the tactile deficit seen among the ageing population. We also discuss appropriate tools and experimental models available to study the age-related tactile decline.
随着年龄的增长，触觉和感知等主要感觉模式的下降已得到充分报道。本综述主要概述了触觉感知的外周组成部分，强调了年龄对皮肤机械换能器和机械敏感离子通道的形态和功能特征、感觉神经支配、神经递质甚至血管系统的影响，这些都是保证皮肤传入神经纤维传出功能所必需的。再加上年龄对皮肤本身和中枢神经系统的影响，可以解释在老年人群中观察到的触觉缺陷。我们还讨论了可用于研究与年龄相关的触觉下降的适当工具和实验模型。
