Stress Physiology Laboratory, Department of Neuroscience, University of Parma, Italy.
Stress Physiology Laboratory, Department of Neuroscience, University of Parma, Italy.
Neurosci Biobehav Rev. 2014 Feb;39:51-60. doi: 10.1016/j.neubiorev.2013.12.005. Epub 2013 Dec 25.
The existence of a close relationship between psychosocial factors and cardiovascular morbidity is not just a hypothesis anymore. Research on humans has been attempting to unravel the significance of this association by investigating psychological and social characteristics in relation to cardiovascular health. However, this research is limited by the difficulty to control and standardize for the individual social history, the impossibility to apply psychosocial stress stimuli for mere experimental purposes, as well as the long time span of cardiovascular pathogenesis in humans. Animal studies controlling for social environment and adverse social episodes since weaning allow for partially overcoming these limitations. The aim of this review is to provide an up-to-date reference of the experimental evidence so far collected on the link between psychosocial factors and cardiovascular (dys-)function in rodent species, with special emphasis on social conflict, aggressiveness and negative mood states, which have been significantly associated with increased risk of cardiovascular disease.
心理社会因素与心血管发病率之间存在密切关系，这不再仅仅是一种假设。人类研究一直在试图通过调查与心血管健康相关的心理和社会特征，来揭示这种关联的意义。然而，这项研究受到个体社会史难以控制和标准化、不可能仅仅出于实验目的施加心理社会压力刺激以及人类心血管发病机制时间跨度长等因素的限制。自断奶以来控制社会环境和不良社会事件的动物研究部分克服了这些限制。本综述的目的是提供迄今为止在啮齿动物物种中收集到的关于心理社会因素与心血管（功能）障碍之间联系的实验证据的最新参考资料，特别强调与心血管疾病风险增加显著相关的社会冲突、攻击性和负面情绪状态。
