用于药物递送的Fe3O4/SiO2/石墨烯-CdTe量子点/壳聚糖纳米复合材料的制备及其细胞相容性
Fabrication and cyto-compatibility of Fe3O4/SiO2/graphene-CdTe QDs/CS nanocomposites for drug delivery.
作者信息
Ou Jun, Wang Fang, Huang Yuanjie, Li Duosheng, Jiang Yuming, Qin Qing-Hua, Stachurski Z H, Tricoli Antonio, Zhang Tina
机构信息
Materials Science and Engineering College, Guilin University of Technology, Guilin 541004, China; Ministry-Province Jointly-Constructed Cultivation Base for State Key Laboratory of Processing for Non-ferrous Metal and Featured Materials, Guangxi Zhuang Autonomous Region, Guilin, China.
Materials Science and Engineering College, Guilin University of Technology, Guilin 541004, China.
出版信息
Colloids Surf B Biointerfaces. 2014 May 1;117:466-72. doi: 10.1016/j.colsurfb.2013.12.003. Epub 2013 Dec 11.
Synthesis of magnetic Fe3O4/SiO2/graphene-CdTe QDs/chitosan nanocomposites (FGQCs) is investigated with respect to their potential of improving the drug loading content above that of magnetic/fluorescent bifunctional nanocomposites. To evaluate the performance of the FGQCs, their surface morphology was thoroughly assessed. The in vitro interaction between the FGQCs and heptoma cell line smmc-7721 cells was observed for the first time by TEM ultrathin section imaging. At an excitation wavelength of 365 nm, the graphene-QDs exhibit a strong luminescence in aqueous environments. The loading content and entrapment efficiency of the FGQCs were 70% and 50%, respectively. The cytotoxicity of this novel drug delivery system was evaluated in vitro using heptoma cell line smmc-7721 and quantified by the 3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that FGQCs are a promising new multifunctional material for drug delivery in biological and medical applications.
研究了磁性Fe3O4/SiO2/石墨烯-CdTe量子点/壳聚糖纳米复合材料（FGQCs）的合成，考察其提高药物负载量的潜力，使其高于磁性/荧光双功能纳米复合材料的药物负载量。为评估FGQCs的性能，对其表面形态进行了全面评估。首次通过透射电子显微镜超薄切片成像观察了FGQCs与肝癌细胞系smmc-7721细胞之间的体外相互作用。在365nm激发波长下，石墨烯量子点在水性环境中表现出强烈的发光。FGQCs的负载量和包封率分别为70%和50%。使用肝癌细胞系smmc-7721在体外评估了这种新型药物递送系统的细胞毒性，并通过3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐（MTT）法进行定量。结果表明，FGQCs是一种在生物和医学应用中用于药物递送的有前景的新型多功能材料。
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