Smooth Muscle Research Group, Department of Biochemistry & Molecular Biology, Libin Cardiovascular Institute of Alberta, Faculty of Medicine, University of Calgary, Alberta, Canada.
Arch Biochem Biophys. 2014 Feb 1;543:48-56. doi: 10.1016/j.abb.2013.12.015. Epub 2013 Dec 25.
Myocardin (MYOCD), a co-transcriptional activator of serum response factor (SRF), stimulates the expression of smooth muscle (SM) genes and inhibits the cell cycle. In addition to its roles in the development, MYOCD may be critically involved in the pathogenesis of proliferative vascular diseases. This review mainly focuses on how MYOCD activity is regulated and how it inhibits cell proliferation.
肌球蛋白结合蛋白 D（MYOCD），一种血清反应因子（SRF）的共转录激活因子，刺激平滑肌（SM）基因的表达并抑制细胞周期。除了在发育中的作用外，MYOCD 可能在增生性血管疾病的发病机制中起着至关重要的作用。本综述主要集中讨论 MYOCD 活性如何受到调节以及它如何抑制细胞增殖。
