225Ac反冲子体核素在聚合物囊泡中的保留研究。

Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles.

作者信息

Wang G, de Kruijff R M, Rol A, Thijssen L, Mendes E, Morgenstern A, Bruchertseifer F, Stuart M C A, Wolterbeek H T, Denkova A G

机构信息

Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands.

Department of Chemical Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft, The Netherlands.

出版信息

Appl Radiat Isot. 2014 Feb;85:45-53. doi: 10.1016/j.apradiso.2013.12.008. Epub 2013 Dec 15.

DOI:10.1016/j.apradiso.2013.12.008

PMID:24374072

Abstract

Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of (221)Fr and (213)Bi when encapsulating (225)Ac.

摘要

α放射性核素疗法正逐渐变得愈发重要，并且已经开展了大量的临床前和临床研究。然而，由于反冲效应，子体反冲原子（其中大多数也是α发射体）获得的能量远高于化学键的能量，导致放射性核素与常见靶向剂解耦。在此，我们通过一项实验研究证明，聚合物囊泡（即聚合物脂质体）能够保留反冲的子核，该实验研究了在包裹（225）Ac时（221）Fr和（213）Bi的保留情况。