Campbell Richard, Gordon Patrick, Ward Katie, Reilly Charles, Scott David L, Rafferty Gerrard F
Department of Academic Rheumatology, King's College London, Weston Education Centre, Cutcombe Road, London SE5 9RJ, UK.
Muscle Nerve. 2014 Sep;50(3):401-6. doi: 10.1002/mus.24148.
We investigated whether muscle endurance differs between IIM patients and controls and if a relationship exists between perceived fatigue and poor muscle endurance.
Quadriceps contractility, measured using femoral nerve stimulation (TwQ), and strength, measured using maximal voluntary contraction (MVCQ), were assessed in 20 IIM patients and matched controls. Quadriceps endurance was assessed using repetitive electrical stimulation (3 minutes). Time for force to fall to 70% initial force was determined (T70). Reported fatigue was measured using the FACIT-F/Fatigue Severity Scales.
TwQ and MVCQ were lower and perceived fatigue greater for patients. There was no difference in T70 between groups. No relationships were observed between perceived fatigue and endurance (T70).
IIM patients reported more fatigue and were weaker than controls, but there was no difference in muscle endurance. Endurance and strength were unrelated to reported fatigue measures. Mechanisms driving perceived IIM fatigue are likely to be multifactorial.
我们研究了炎性肌病（IIM）患者与对照组之间的肌肉耐力是否存在差异，以及感知疲劳与肌肉耐力差之间是否存在关联。
对20例IIM患者及匹配的对照组进行评估，通过股神经刺激测量股四头肌收缩力（TwQ），并使用最大自主收缩测量股四头肌力量（MVCQ）。通过重复电刺激（3分钟）评估股四头肌耐力。确定力量降至初始力量70%的时间（T70）。使用功能性评估癌症治疗-疲劳量表（FACIT-F）/疲劳严重程度量表测量报告的疲劳程度。
患者的TwQ和MVCQ较低，感知疲劳程度更高。两组之间的T70没有差异。在感知疲劳与耐力（T70）之间未观察到相关性。
IIM患者报告的疲劳更多，且比对照组虚弱，但肌肉耐力没有差异。耐力和力量与报告的疲劳测量指标无关。导致IIM患者感知疲劳的机制可能是多因素的。
