Pardini Matteo, Bergamino Maurizio, Bommarito Giulia, Bonzano Laura, Luigi Mancardi Gian, Roccatagliata Luca
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy; Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Genoa, Italy.
Hippocampus. 2014 Apr;24(4):436-45. doi: 10.1002/hipo.22237. Epub 2013 Dec 23.
Subjective and objective memory deficits represent a frequent and ill-understood aspect of multiple sclerosis (MS), and a significant cause of disability and quality of life reduction. The aim of the study is to verify the role of hippocampal and temporal associative fibers' damage in MS-related memory complaints. To reach this aim, 25 patients with low disability relapsing-remitting MS and 19 healthy controls were included in the study. All subjects underwent 3D T1 structural imaging and Diffusion Tensor Imaging. Additionally, MS patients underwent neuropsychological evaluation of objective (Selective Reminding Test and Spatial Recall Test) and of subjective (Perceived Deficit Questionnaire, Retrospective and Prospective Memory Subscales) memory deficits. Normalized hippocampal volume (NHV) and mean Fractional Anisotropy (FA) for the uncinate fasciculus (UF) and for the ventral division of the cingulum bundle (VCB) were calculated for all subjects. We showed that, compared to controls, MS subjects presented with reduced right NHV and with reduced mean FA bilaterally in the UF and the VCB. In the MS group, verbal memory scores correlated with left NHV, spatial memory scores correlated with right NHV, while perceived retrospective and prospective memory deficits correlated with left VCB and left UF mean FA respectively. Our data confirm an early involvement of memory-related brain structures in MS patients. Our data suggest that verbal and nonverbal memory as well as perceived retrospective and prospective memory deficits are related to alterations of discrete anatomical structures in the low-disability phase of MS.
主观和客观记忆缺陷是多发性硬化症（MS）常见但尚未完全理解的一个方面，也是导致残疾和生活质量下降的一个重要原因。本研究的目的是验证海马体和颞叶联合纤维损伤在MS相关记忆障碍中的作用。为实现这一目标，本研究纳入了25例低残疾复发缓解型MS患者和19名健康对照者。所有受试者均接受了3D T1结构成像和弥散张量成像。此外，MS患者还接受了客观（选择性提醒测试和空间回忆测试）和主观（感知缺陷问卷、回顾性和前瞻性记忆子量表）记忆缺陷的神经心理学评估。计算了所有受试者的标准化海马体积（NHV）以及钩束（UF）和扣带束腹侧分支（VCB）的平均分数各向异性（FA）。我们发现，与对照组相比，MS患者右侧NHV减小，UF和VCB双侧平均FA降低。在MS组中，言语记忆分数与左侧NHV相关，空间记忆分数与右侧NHV相关，而感知到的回顾性和前瞻性记忆缺陷分别与左侧VCB和左侧UF平均FA相关。我们的数据证实了MS患者中与记忆相关的脑结构早期受累。我们的数据表明，言语和非言语记忆以及感知到的回顾性和前瞻性记忆缺陷与MS低残疾期离散解剖结构的改变有关。
