Kanawade Rajesh, Mahari Fanuel, Klämpfl Florian, Rohde Maximilian, Knipfer Christian, Tangermann-Gerk Katja, Adler Werner, Schmidt Michael, Stelzle Florian
Clinical Photonics Lab, Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 6, 91052, Erlangen, Germany; Institute of Photonics Technologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Konrad-Zuse-Straße 3/5, 91052 Erlangen, Germany.
J Biophotonics. 2015 Jan;8(1-2):153-61. doi: 10.1002/jbio.201300159. Epub 2013 Dec 23.
The research work presented in this paper focuses on qualitative tissue differentiation by monitoring the intensity ratios of atomic emissions using 'Laser Induced Breakdown Spectroscopy' (LIBS) on the plasma plume created during laser tissue ablation. The background of this study is to establish a real time feedback control mechanism for clinical laser surgery systems during the laser ablation process. Ex-vivo domestic pig tissue samples (muscle, fat, nerve and skin) were used in this experiment. Atomic emission intensity ratios were analyzed to find a characteristic spectral line for each tissue. The results showed characteristic elemental emission intensity ratios for the respective tissues. The spectral lines and intensity ratios of these specific elements varied among the different tissue types. The main goal of this study is to qualitatively and precisely identify different tissue types for tissue specific laser surgery.
本文所呈现的研究工作聚焦于通过使用“激光诱导击穿光谱法”（LIBS）监测原子发射强度比，对组织进行定性分化，该方法应用于激光组织消融过程中产生的等离子体羽流。本研究的背景是为临床激光手术系统在激光消融过程中建立一种实时反馈控制机制。本实验使用了离体的家猪组织样本（肌肉、脂肪、神经和皮肤）。分析原子发射强度比以找到每种组织的特征光谱线。结果显示了各组织的特征元素发射强度比。这些特定元素的光谱线和强度比在不同组织类型中有所不同。本研究的主要目标是为组织特异性激光手术定性且精确地识别不同的组织类型。
