骨原发性血管肉瘤。病例报告。
Primary angiosarcoma of bone. A case report.
作者信息
Baliaka A, Balis Gc, Michalopoulou-Manoloutsiou E, Papanikolaou A, Nikolaidou A
机构信息
Department of Pathology, Cancer Hospital of Thessaloniki "Theagenio"
Department of Pathology, General Hospital of Thessaloniki "G.Gennimatas", Thessaloniki, Greece.
出版信息
Hippokratia. 2013 Apr;17(2):180-2.
BACKGROUND
Primary malignant vascular tumors of bone are very rare accounting for less than 1% of primary bone malignancies. They are characterized by unknown etiology, variable biologic behavior and histological appearance. Angiosarcoma is an aggressive malignant vascular tumor derived from mesenchymal cells with endothelial differentiation.
CASE REPORT
We present a rare case of angiosarcoma of bone in a 47-year-old male operated for a lumbar disk herniation. During his transportation from the operation theater, a pathological intertrochanteric fracture of the right hip occured. The magnetic resonance imaging (MRI) revealed a bone lytic lesion located into the great trochanter of the right femur. Open surgical biopsy of the lesion was performed and the histological examination showed primary angiosarcoma of bone. The treatment included radiotherapy (300 cGy per fraction in 13 days) followed by excision of the proximal femur and custom made total hip arthroplasty. The diagnosis was confirmed on the surgical specimen.
背景
原发性骨恶性血管肿瘤非常罕见，占原发性骨恶性肿瘤的比例不到1%。它们的特点是病因不明、生物学行为和组织学表现各异。血管肉瘤是一种侵袭性恶性血管肿瘤，起源于具有内皮分化的间充质细胞。
病例报告
我们报告一例罕见的骨血管肉瘤病例，患者为一名47岁男性，因腰椎间盘突出症接受手术治疗。在从手术室转运过程中，患者右髋部发生病理性粗隆间骨折。磁共振成像（MRI）显示右股骨大粗隆处有一个骨质溶解病变。对该病变进行了开放手术活检，组织学检查显示为原发性骨血管肉瘤。治疗包括放疗（13天内每次300厘戈瑞），随后切除股骨近端并进行定制全髋关节置换术。手术标本确诊了该诊断。
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