Polom Karol, Murawa Dawid, Michalak Michał, Murawa Paweł
1st Surgical Oncology and General Surgery Dept., Wielkopolska Cancer Centre, Garbary 15, Poznan, Poland.
Biostatistics Dept., University of Medical Sciences, Poznan, Poland.
Rep Pract Oncol Radiother. 2011 Apr 8;16(3):82-6. doi: 10.1016/j.rpor.2011.02.005. eCollection 2011.
Sentinel node biopsy (SNB) is a gold standard in staging of early breast cancer. Nowadays, routine mapping of lymphatic tract is based on two tracers: human albumin with radioactive technetium, with or without blue dye. Recent years have seen a search for new tracers to examine sentinel node as well as lymphatic network. One of them is indocyanine green (ICG) visible in infrared light.
The aim of this study is to evaluate clinical usage of ICG in comparison with standard tracer, i.e. nanocoll, in SNB of breast cancer patients.
In the 1st Department of Surgical Oncology and General Surgery, Greater Poland Cancer Centre, Poznań, 13 female breast cancer patients have benn operated since September 2010. All these patients had sentinel node biopsy with nanocoll (human albumin with radioactive technetium), and with indocyanine green. The feasibility of this new method was assessed in comparison with the standard nanocoll.
A lymphatic network between the place of injection of ICG and sentinel node was seen in infrared light. An area where a sentinel node was possibly located was confirmed by gamma probe. Sensitivity of this method was 100%.
SNB using ICG is a new, promising diagnostics technique. This procedure is not without drawbacks; nevertheless it opens new horizons in lymphatic network diagnostics.
前哨淋巴结活检（SNB）是早期乳腺癌分期的金标准。如今，淋巴道的常规定位基于两种示踪剂：含放射性锝的人白蛋白，可使用或不使用蓝色染料。近年来一直在寻找用于检查前哨淋巴结以及淋巴网络的新型示踪剂。其中一种是在红外光下可见的吲哚菁绿（ICG）。
本研究的目的是评估在乳腺癌患者的前哨淋巴结活检中，吲哚菁绿与标准示踪剂（即纳米碳混悬液）相比的临床应用情况。
在波兹南大波兰癌症中心外科肿瘤学与普通外科第一科室，自2010年9月起对13例女性乳腺癌患者进行了手术。所有这些患者均接受了纳米碳混悬液（含放射性锝的人白蛋白）和吲哚菁绿的前哨淋巴结活检。与标准的纳米碳混悬液相比，评估了这种新方法的可行性。
在红外光下可见吲哚菁绿注射部位与前哨淋巴结之间的淋巴网络。通过γ探测仪确定了前哨淋巴结可能所在的区域。该方法的敏感性为100%。
使用吲哚菁绿的前哨淋巴结活检是一种新的、有前景的诊断技术。该方法并非没有缺点；然而，它为淋巴网络诊断开辟了新的前景。
