乳腺原发性鳞状细胞癌：一例罕见病例报告。
Primary squamous cell carcinoma of the breast: A rare case report.
作者信息
Carbone Stefania, Lobo Alvarez Rosabel, Lamacchia Annalisa, Almenar Gil Asuncion, Martin Hernandez Raquel, Lopez Guerra Jose Luis, Marsiglia Hugo
机构信息
Department of Radiation Oncology, Instituto Madrileño de Oncologia/Grupo IMO, Madrid, Spain.
Department of Radiation Oncology, Instituto Oncologico de Castilla La Mancha/Grupo IMO, Toledo, Spain.
出版信息
Rep Pract Oncol Radiother. 2012 Aug 9;17(6):363-6. doi: 10.1016/j.rpor.2012.07.004. eCollection 2012.
BACKGROUND
Squamous cells are normally not found inside the breast. Therefore, a primary squamous cell carcinoma of the breast is an exceptional phenomenon and the management of this type of disease is still debated.
AIM
Clinical outcome assessment of a patient with squamous cell carcinoma of the breast.
MATERIALS AND METHODS
We report a case of primary squamous cell carcinoma of the breast (T1cN0M0) in a 51-years-old woman who underwent breast conserving surgery plus adjuvant chemotherapy and radiation therapy (RT).
RESULTS
With a follow up of 43 months, the patient is alive with no evidence of local or distant recurrence. The patient had Grade 2 acute skin toxicity. No late skin or respiratory toxicity was observed.
CONCLUSIONS
Pure primary squamous cell carcinoma of the breast is a rare and aggressive disease, often treatment-refractory. Our case shows that the addition of RT after breast conserving surgery, allows to achieve a high local control without adding severe toxicity. A multidisciplinary approach seems to be the optimal management for early stages in this rare disease.
背景
乳腺内部通常不会发现鳞状细胞。因此，原发性乳腺鳞状细胞癌是一种罕见现象，此类疾病的治疗仍存在争议。
目的
对一名乳腺鳞状细胞癌患者的临床结局进行评估。
材料与方法
我们报告一例51岁女性原发性乳腺鳞状细胞癌（T1cN0M0）病例，该患者接受了保乳手术加辅助化疗及放疗（RT）。
结果
随访43个月，患者存活，无局部或远处复发迹象。患者出现2级急性皮肤毒性。未观察到晚期皮肤或呼吸道毒性。
结论
单纯原发性乳腺鳞状细胞癌是一种罕见且侵袭性强的疾病，通常对治疗耐药。我们的病例表明，保乳手术后加用放疗可在不增加严重毒性的情况下实现较高的局部控制率。多学科方法似乎是这种罕见疾病早期阶段的最佳治疗方式。
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