Zlatopol'skiĭ A D, Zaĭdenberg M A, Berman A E, Mazurov V I, Karelin A A
Vopr Med Khim. 1987 Jan-Feb;33(1):116-8.
Human blood plasma fibronectin decreased slightly the incorporation of precursors into nucleic acids of granulation tissue culture cells. A slight fragmentation of fibronectin, where the fragments with 180-200 kD molecular mass were developed, led to occurrence of the activity 2-fold stimulating the DNA synthesis. After more effective proteolysis using plasmin and trypsin the stimulating effect of fibronectin fragments on synthesis of nucleic acids maintained and constituted 165 +/- 12% and 127 +/- 7% for DNA and RNA, respectively.
人血浆纤连蛋白略微降低了前体物质掺入肉芽组织培养细胞核酸中的量。纤连蛋白出现了轻微的片段化，形成了分子量为180 - 200 kD的片段，导致出现了刺激DNA合成2倍的活性。在使用纤溶酶和胰蛋白酶进行更有效的蛋白水解后，纤连蛋白片段对核酸合成的刺激作用得以维持，DNA和RNA的刺激作用分别为165±12%和127±7%。
