Qin Ling-Yan, Chen Xu, Li Ping, Yang Zheng, Mo Wu-Ning
Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China E-mail :
Asian Pac J Cancer Prev. 2014 Jan;14(11):6703-7. doi: 10.7314/apjcp.2013.14.11.6703.
Numerous epidemiological studies have been conducted to evaluate the association between variants of the DNA repair gene XRCC3 and cancer risk. Here we focused on one XRCC3 polymorphism and development of cervical cancer, performing a meta-analysis.
The pooled association between the XRCC3 Thr241Met polymorphism and cervical cancer risk was assessed by odds ratios (ORs) and their 95% confidence intervals (95%CIs).
A total of 5 case-control studies met the inclusion criteria. The pooled ORs for the total included studies showed no association among homozygotes TT vs. CC: OR=1.93, 95%CI=0.68- 5.49, P=0.22; dominant model TT<TC vs. CC: OR=1.37, 95%CI=0.90-2.06, P=0.14; and recessive model TT vs. TC<CC: OR=1.76, 95%CI=0.68-4.55, P=0.25, but might be a slight risk factor for cervical cancer in heterozygote contrast TT vs. CT: OR= 1.33, 95%CI=1.04-1.71, P=0.02. In subgroup analysis, significant associations were found for Asians under all genetic models.
Our meta-analysis suggested the XRCC3 Thr241Met polymorphism might not act as a cervical cancer risk factor overall. However, in subgroup analysis, a significant association was found in Asians under all genetic models. The association should be studied with a larger, stratified population, especially for Asians.
已经开展了大量流行病学研究来评估DNA修复基因XRCC3的变异与癌症风险之间的关联。在此，我们聚焦于一种XRCC3多态性与宫颈癌的发生发展，进行了一项荟萃分析。
通过比值比（OR）及其95%置信区间（95%CI）评估XRCC3 Thr241Met多态性与宫颈癌风险之间的合并关联。
共有5项病例对照研究符合纳入标准。纳入研究的总体合并OR显示，纯合子TT与CC之间无关联：OR = 1.93，95%CI = 0.68 - 5.49，P = 0.22；显性模型TT<TC与CC：OR = 1.37，95%CI = 0.90 - 2.06，P = 0.14；隐性模型TT与TC<CC：OR = 1.76，95%CI = 0.68 - 4.55，P = 0.25，但杂合子对比TT与CT可能是宫颈癌的一个轻微危险因素：OR = 1.33，95%CI = 1.04 - 1.71，P = 0.02。在亚组分析中，在所有遗传模型下亚洲人均发现显著关联。
我们的荟萃分析表明，总体而言XRCC3 Thr241Met多态性可能不是宫颈癌的危险因素。然而，在亚组分析中，在所有遗传模型下亚洲人均发现显著关联。应在更大的分层人群中研究这种关联，尤其是针对亚洲人群。
