Department of Epidemiology, School of Public Health, Guilin Medical University, Guilin 541004, China.
Department of Oncology, Ezhou Central Hospital, Ezhou 436000, China.
Cancer Genet. 2021 Jun;254-255:11-17. doi: 10.1016/j.cancergen.2021.01.003. Epub 2021 Jan 13.
Studies have investigated the relationship between the X-ray cross- complementing group 3 (XRCC3) Thr241Met polymorphism and the risk of gynecological malignancies (GM) with the contradictory conclusions. Here, a meta-analysis was performed to provide clear picture of the association between Thr241Met and GM risk. The Pubmed and Chinese National Knowledge Infrastructure (CNKI) databases were searched for published eligible studies. The pooled odds ratios (OR) with their corresponding 95% confidence interval (CI) was used to assessed the strength of association. Totally, 15 publications with 5,740 cases and 9,931 controls were included. In the overall analysis, the results of meta-analysis showed no significant association between the Thr241Met and the risk of GM. However, in the Asians subgroup, significant increased risks were found in the comparisons of TT/CT+TT vs. CC(TT vs. CC: OR=3.25, 95% CI=1.47-7.18; CT+TT vs. CC: OR=1.51, 95%CI=1.10-2.09) in Asians; additionally, stratified analysis by cancer type in Asians, significantly increased risks was found in cervical carcinoma (CT vs. CC: OR=1.50, 95%CI=1.04-2.14; TT vs. CC: OR=3.14, 95%CI=1.38-7.14; CT+TT vs. CC: OR=1.64, 95% CI=1.17-2.31). It suggests that the risk of GM might be significantly increased by the XRCC3 Thr241Met polymorphism according to ethnicity and cancer types. Further studies with larger sample size in different ethnic populations and different sites of GM are needed to verify the findings.
研究已经调查了 X 射线交叉互补群 3（XRCC3）Thr241Met 多态性与妇科恶性肿瘤（GM）风险之间的关系，但其结论存在矛盾。在这里，进行了一项荟萃分析，以提供 Thr241Met 与 GM 风险之间关联的清晰图像。检索了 Pubmed 和中国国家知识基础设施（CNKI）数据库中已发表的合格研究。使用合并的优势比（OR）及其相应的 95％置信区间（CI）来评估关联的强度。总共纳入了 15 项研究，共 5740 例病例和 9931 例对照。在总体分析中，荟萃分析的结果表明，Thr241Met 与 GM 风险之间没有显著关联。但是，在亚洲人群亚组中，TT/CT+TT 与 CC 的比较（TT 与 CC：OR=3.25，95％CI=1.47-7.18；CT+TT 与 CC：OR=1.51，95％CI=1.10-2.09）和 CT 与 CC 的比较（OR=1.50，95％CI=1.04-2.14；TT 与 CC：OR=3.14，95％CI=1.38-7.14；CT+TT 与 CC：OR=1.64，95％CI=1.17-2.31）均发现风险显著增加。这表明，根据种族和癌症类型，XRCC3 Thr241Met 多态性可能会显著增加 GM 的风险。需要在不同种族人群和 GM 的不同部位进行更大样本量的进一步研究，以验证这些发现。
