Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523, United States.
Org Lett. 2014 Jan 17;16(2):432-5. doi: 10.1021/ol403320d. Epub 2013 Dec 30.
Stereoselective alkylations of proline-based amino amides are described, where high levels of either a cis or trans configuration can be attained simply by the choice of the aminal group. Isobutryaldehyde-derived aminals provide the cis configuration, while 1-naphthaldehyde-derived aminals engender the complementary trans configuration.
本文介绍了脯氨酸衍生的酰胺基氨基酸的立体选择性烷基化反应，通过选择亚胺基团，可以简单地获得高比例的顺式或反式构型。异丁醛衍生的亚胺提供顺式构型，而 1-萘醛衍生的亚胺则产生互补的反式构型。
