Di Lorenzo Francesco, Di Lorenzo Berardino
"Ambulatorio Privato di Scienze Mediche", Valenzano, Bari, Italy.
Neuro Endocrinol Lett. 2013;34(6):504-7.
In this case presentation, a woman with high serum levels of aluminum was treated with chelation therapy with deferoxamine and ascorbic acid. This patient was initially bedridden and the clinical situation was complicated by epileptic seizures. After the chelation therapy, the clinical condition was ameliorated and the therapy continued without the correlation to aluminum serum levels. The role of metals in neurodegenerative disorders and the correlation between iron metabolism and amyloid beta peptide are described. This case suggests chelation therapy could represent a promising therapeutic option for this dramatic disease.
在本病例报告中，一名血清铝水平较高的女性接受了去铁胺和抗坏血酸的螯合疗法。该患者最初卧床不起，临床情况因癫痫发作而复杂化。螯合治疗后，临床状况得到改善，治疗持续进行，且与血清铝水平无关。文中描述了金属在神经退行性疾病中的作用以及铁代谢与β-淀粉样肽之间的相关性。该病例表明螯合疗法可能是这种严重疾病一种有前景的治疗选择。
