Salvetti Anna, Greco Anna
Centre International de Recherche en Infectiologie (CIRI, International Center for Infectiology Research), Inserm U1111, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, 46 Allée d'Italie, 69365 Lyon CEDEX, France; LabEx Ecofect, Université de Lyon, 69007 Lyon, France.
Biochim Biophys Acta. 2014 Jun;1842(6):840-7. doi: 10.1016/j.bbadis.2013.12.010. Epub 2013 Dec 27.
Viruses are small obligatory parasites and as a consequence, they have developed sophisticated strategies to exploit the host cell's functions to create an environment that favors their own replication. A common feature of most - if not all - families of human and non-human viruses concerns their interaction with the nucleolus. The nucleolus is a multifunctional nuclear domain, which, in addition to its well-known role in ribosome biogenesis, plays several crucial other functions. Viral infection induces important nucleolar alterations. Indeed, during viral infection numerous viral components localize in nucleoli, while various host nucleolar proteins are redistributed in other cell compartments or are modified, and non-nucleolar cellular proteins reach the nucleolus. This review highlights the interactions reported between the nucleolus and some human or animal viral families able to establish a latent or productive infection, selected on the basis of their known interactions with the nucleolus and the nucleolar activities, and their links with virus replication and/or pathogenesis. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
病毒是小型专性寄生虫，因此，它们已发展出复杂的策略来利用宿主细胞的功能，以创造有利于自身复制的环境。大多数（即便不是全部）人类和非人类病毒家族的一个共同特征涉及其与核仁的相互作用。核仁是一个多功能的核结构域，除了在核糖体生物合成中众所周知的作用外，还发挥着其他几个关键功能。病毒感染会引起重要的核仁变化。事实上，在病毒感染期间，许多病毒成分定位于核仁，而各种宿主核仁蛋白会重新分布到其他细胞区室或被修饰，并且非核仁细胞蛋白会进入核仁。本综述重点介绍了核仁与一些能够建立潜伏性或增殖性感染的人类或动物病毒家族之间已报道的相互作用，这些病毒家族是根据它们与核仁及核仁活动的已知相互作用、以及它们与病毒复制和/或发病机制的联系来挑选的。本文是名为《核仁在人类疾病中的作用》的特刊的一部分。
