Scottish Crop Research Institute, Invergowrie, Dundee, United Kingdom.
Adv Virus Res. 2010;77:119-58. doi: 10.1016/B978-0-12-385034-8.00005-3.
The nucleolus is a dynamic subnuclear body with roles in ribosome subunit biogenesis, mediation of cell-stress responses, and regulation of cell growth. An increasing number of reports reveal that similar to the proteins of animal viruses, many plant virus proteins localize in the nucleolus to divert host nucleolar proteins from their natural functions in order to exert novel role(s) in the virus infection cycle. This chapter will highlight studies showing how plant viruses recruit nucleolar functions to facilitate virus translation and replication, virus movement and assembly of virus-specific ribonucleoprotein (RNP) particles, and to counteract plant host defense responses. Plant viruses also provide a valuable tool to gain new insights into novel nucleolar functions and processes. Investigating the interactions between plant viruses and the nucleolus will facilitate the design of novel strategies to control plant virus infections.
核仁是一个具有核糖体亚基生物发生、细胞应激反应中介和细胞生长调节作用的动态亚核体。越来越多的报道表明，类似于动物病毒的蛋白质，许多植物病毒蛋白定位于核仁，使宿主核仁蛋白从其自然功能中转移，以便在病毒感染周期中发挥新的作用。本章将重点介绍研究如何招募核仁功能来促进病毒翻译和复制、病毒运动和病毒特异性核糖核蛋白 (RNP) 颗粒的组装，并抵抗植物宿主防御反应。植物病毒也为深入了解新的核仁功能和过程提供了有价值的工具。研究植物病毒与核仁之间的相互作用将有助于设计控制植物病毒感染的新策略。
