Leukaemia Foundation Research Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia.
Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.
Nat Rev Drug Discov. 2014 Jan;13(1):39-62. doi: 10.1038/nrd4175.
Critical roles for EPH receptor (EPH)-ephrin signalling in a range of chronic and regenerative diseases are increasingly being recognized. In particular, the complex roles of EPHs and ephrins in tumour growth and progression, and in nerve injury and regeneration have been studied extensively. This has led to considerable progress in developing strategies for their therapeutic targeting, with some anticancer agents already in clinical trials. Promising leads for non-malignant diseases are also emerging, with compelling preclinical data encouraging clinical development. We discuss this rapidly developing area of drug discovery, highlighting the associated challenges and limitations.
EPH 受体（EPH）-ephrin 信号在一系列慢性和再生性疾病中的关键作用正日益受到关注。特别是，EPH 和 ephrins 在肿瘤生长和进展以及神经损伤和再生中的复杂作用已得到广泛研究。这为针对它们的治疗方法的开发带来了显著的进展，一些抗癌药物已经在临床试验中。在非恶性疾病方面也出现了有希望的研究线索，令人信服的临床前数据鼓励了临床开发。我们讨论了这一快速发展的药物发现领域，强调了相关的挑战和局限性。
