Yoon Jeong Hee, Lee Jeong Min, Baek Jee Hyun, Shin Cheong-il, Kiefer Berthold, Han Joon Koo, Choi Byung-Ihn
From the *Department of Radiology, Seoul National University Hospital; and †Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea; and ‡Siemens Healthcare, Erlangen, Germany.
J Comput Assist Tomogr. 2014 Jan-Feb;38(1):110-6. doi: 10.1097/RCT.0b013e3182a589be.
To determine whether intravoxel incoherent motion (IVIM)-diffusion-weighted image (DWI)-derived parameters showed better diagnostic performance than the apparent diffusion coefficient (ADC(total)) for the evaluation of hepatic fibrosis (HF).
This retrospective study was approved by institutional review board, and informed consent was waived. Fifty-five patients with chronic liver disease who had undergone IVIM-DWI using 8 b-values at 3 T were included. True diffusion coefficient (Dt), pseudo-diffusion coefficient (Dp), perfusion fraction (f), and ADC(total) were calculated. Receiver operating characteristic analysis was performed for all parameters for the HF staging.
All parameters showed a significant correlation with the HF stages (-0.31 to -0.72, P < 0.05). All parameters were significantly higher in F0 to F1 than in F4 (P < 0.05). The Dp showed better performance than the ADC(total) in differentiating significant HF (≥F2) from F0 to F1.
The IVIM-derived parameters and ADC(total) showed significant correlation with HF. The D p showed better diagnostic performance for differentiating significant HF than did ADC(total).
确定体素内不相干运动（IVIM）-扩散加权成像（DWI）衍生参数在评估肝纤维化（HF）方面是否比表观扩散系数（ADC（总））具有更好的诊断性能。
本回顾性研究经机构审查委员会批准，且无需知情同意。纳入了55例在3T下使用8个b值进行IVIM-DWI检查的慢性肝病患者。计算真扩散系数（Dt）、伪扩散系数（Dp）、灌注分数（f）和ADC（总）。对所有参数进行HF分期的受试者工作特征分析。
所有参数均与HF分期显著相关（-0.31至-0.72，P<0.05）。F0至F1期的所有参数均显著高于F4期（P<0.05）。在区分显著HF（≥F2）与F0至F1方面，Dp比ADC（总）表现更好。
IVIM衍生参数和ADC（总）与HF显著相关。在区分显著HF方面，Dp比ADC（总）具有更好的诊断性能。
