Pediatrics. 2014 Jan;133(1):164-70. doi: 10.1542/peds.2013-3444. Epub 2013 Dec 30.
Nitric oxide, an important signaling molecule with multiple regulatory effects throughout the body, is an important tool for the treatment of full-term and late-preterm infants with persistent pulmonary hypertension of the newborn and hypoxemic respiratory failure. Several randomized controlled trials have evaluated its role in the management of preterm infants ≤ 34 weeks' gestational age with varying results. The purpose of this clinical report is to summarize the existing evidence for the use of inhaled nitric oxide in preterm infants and provide guidance regarding its use in this population.
一氧化氮，一种重要的信号分子，具有多种全身调节作用，是治疗足月和晚期早产儿持续性肺动脉高压和低氧性呼吸衰竭的重要工具。几项随机对照试验评估了其在不同胎龄（≤34 周）早产儿管理中的作用，结果不一。本临床报告的目的是总结吸入一氧化氮在早产儿中的应用证据，并为该人群中的应用提供指导。
