Neu Madalynn, Pan Zhaoxing, Workman Rachel, Marcheggiani-Howard Cassandra, Furuta Glenn, Laudenslager Mark L
University of Colorado Anschutz Medical Campus, College of Nursing, Denver, CO, USA
Department of Pediatrics, University of Colorado, School of Medicine, Anschutz Medical Campus, Denver, CO, USA.
Biol Res Nurs. 2014 Oct;16(4):387-97. doi: 10.1177/1099800413516187. Epub 2013 Dec 30.
This randomized controlled pilot trial was conducted to evaluate the clinical efficacy of massage therapy (MT) for relief of symptoms of gastroesophageal reflux disease (GERD). The hypothesis was that, when compared to infants who received nonmassage therapy, infants who received MT would display fewer GERD symptoms, greater weight gain, greater amount of sleep, lower cortisol levels before and after treatment, and lower daily (area under the curve [AUC]) cortisol secretion.
Participants were 36 infants born at term, 4-10 weeks of age at enrollment, healthy except for a diagnosis of GERD by their pediatrician, and with a score of at least 16 on the Infant Gastroesophageal Reflux Questionnaire-Revised (I-GERQ-R). Infants were randomized to receive either MT or a nonmassage sham treatment in their homes for 30 min twice a week for 6 weeks. Data collectors and parents were blind to study condition.
GERD symptoms decreased in both groups and weight increased. Pretreatment salivary cortisol levels decreased significantly over time in the massage group while increasing in the nonmassage group. Daily cortisol level also decreased in the massage group and increased in the nonmassage group, but the difference was not significant.
MT administered by a professional therapist did not affect symptoms of GERD differently than a sham treatment but did decrease infant stress as measured by cortisol. Research focusing on stress reduction in infants with GERD and multimodal treatments addressing GERD symptoms may yield the most effective treatment.
本随机对照试验旨在评估按摩疗法（MT）缓解胃食管反流病（GERD）症状的临床疗效。假设是，与接受非按摩疗法的婴儿相比，接受MT的婴儿GERD症状更少、体重增加更多、睡眠时间更长、治疗前后皮质醇水平更低，且每日（曲线下面积[AUC]）皮质醇分泌量更低。
参与者为36名足月出生的婴儿，入组时年龄为4 - 10周，除经儿科医生诊断患有GERD外身体健康，且在婴儿胃食管反流问卷修订版（I - GERQ - R）上得分至少为16分。婴儿被随机分为两组，一组在家中接受MT，另一组接受非按摩假治疗，每周两次，每次30分钟，共6周。数据收集者和家长对研究情况不知情。
两组的GERD症状均有所减轻，体重均有所增加。按摩组的预处理唾液皮质醇水平随时间显著下降，而非按摩组则升高。按摩组的每日皮质醇水平也下降，非按摩组则升高，但差异不显著。
由专业治疗师实施的MT与假治疗相比，对GERD症状的影响并无差异，但通过皮质醇测量确实降低了婴儿的应激。针对GERD婴儿减压以及针对GERD症状的多模式治疗的研究可能会产生最有效的治疗方法。
