Faculté de Médecine, U1020, Université Paris-Descartes, INSERM , Paris , France.
Faculté de Médecine, U1002, Université Paris-Descartes, INSERM , Paris , France.
Front Immunol. 2013 Dec 16;4:452. doi: 10.3389/fimmu.2013.00452. eCollection 2013.
Inflammatory reactions are believed to be triggered by innate signals and have a major protective role by recruiting innate immunity cells, favoring lymphocyte activation and differentiation, and thus contributing to the sequestration and elimination of the injurious stimuli. Although certain lymphocyte types such as TH17 cells co-participate in inflammatory reactions, their generation from the naïve pool requires the pre-existence of an inflammatory milieu. In this context, inflammation is always regarded as beginning with an innate response that may be eventually perpetuated and amplified by certain lymphocyte types. In contrast, we here show that even in sterile immunizations or in MyD88-deficient mice, CD8 T cells produce a burst of pro-inflammatory cytokines and chemokines. These functions follow opposite rules to the classic CD8 effector functions since they are generated prior to cell expansion and decline before antigen elimination. As few as 56 CD8(+) inflammatory effector cells in a lymph node can mobilize 10(7) cells in 24 h, including lymphocytes, natural killer cells, and several accessory cell types involved in inflammatory reactions. Thus, although inflammation modulates cognate responses, CD8 cognate responses also initiate local inflammatory reactions.
炎症反应被认为是由先天信号触发的，通过招募先天免疫细胞发挥主要的保护作用，有利于淋巴细胞的激活和分化，从而有助于隔离和消除有害刺激。尽管某些淋巴细胞类型（如 TH17 细胞）共同参与炎症反应，但它们从幼稚池中产生需要炎症环境的预先存在。在这种情况下，炎症总是被认为始于先天反应，而某些淋巴细胞类型可能会使先天反应持续和放大。相比之下，我们在这里表明，即使在无菌免疫或 MyD88 缺陷小鼠中，CD8 T 细胞也会产生一波促炎细胞因子和趋化因子。这些功能与经典的 CD8 效应功能相反，因为它们是在细胞扩增之前产生的，并且在抗原清除之前下降。在淋巴结中，仅 56 个 CD8(+)炎症效应细胞就可以在 24 小时内动员 10(7)个细胞，包括淋巴细胞、自然杀伤细胞和几种参与炎症反应的辅助细胞类型。因此，尽管炎症调节同源反应，但 CD8 同源反应也会引发局部炎症反应。
