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本文引用的文献

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Passive protection of diabetic rats with antisera specific for the polysaccharide portion of the lipopolysaccharide isolated from Pseudomonas pseudomallei.用针对从类鼻疽假单胞菌分离的脂多糖多糖部分的抗血清对糖尿病大鼠进行被动保护。
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Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis.类鼻疽杆菌中LolC同源物的鉴定，一种类鼻疽病的新型保护性抗原。
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针对鼻内接种和攻毒的亚单位疫苗接种的保护性反应。

Protective response to subunit vaccination against intranasal and challenge.

作者信息

Whitlock Gregory C, Deeraksa Arpaporn, Qazi Omar, Judy Barbara M, Taylor Katherine, Propst Katie L, Duffy Angie J, Johnson Kate, Kitto G Barrie, Brown Katherine A, Dow Steven W, Torres Alfredo G, Estes D Mark

机构信息

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555-1070 ; Department of Clinical Laboratory Sciences, University of Texas Medical Branch, Galveston, Texas 77555-1070.

Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-1070.

出版信息

Procedia Vaccinol. 2010;2(1). doi: 10.1016/j.provac.2010.03.013.

DOI:10.1016/j.provac.2010.03.013
PMID:24379895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3874274/
Abstract

and are Gram-negative pathogenic bacteria, responsible for the diseases glanders and melioidosis, respectively. Furthermore, there is currently no vaccine available against these species. In this study, we aimed to identify protective proteins against these pathogens. Immunization with recombinant Hcp1 (type VI secreted/structural protein), BimA (autotransporter protein), BopA (type III secreted protein), and LolC (ABC transporter protein) generated significant protection against lethal inhaled ATCC23344 and 1026b challenge. Immunization with BopA elicited the greatest protective activity, resulting in 100% and 60% survival against and challenge, respectively. Moreover, sera from recovered mice demonstrated reactivity with the recombinant proteins. Dendritic cells stimulated with each of the different recombinant proteins showed distinct cytokine patterns. In addition, T cells from immunized mice produced IFN-γ following re-stimulation. These results indicated therefore that it was possible to elicit cross-protective immunity against both and by vaccinating animals with one or more novel recombinant proteins identified in .

摘要

伯克霍尔德菌属 和 类鼻疽伯克霍尔德菌 是革兰氏阴性病原菌，分别引发鼻疽病和类鼻疽病。此外，目前尚无针对这些 伯克霍尔德菌属 菌种的疫苗。在本研究中，我们旨在鉴定针对这些病原体的保护性蛋白。用重组 嗜肺军团菌 Hcp1（VI型分泌/结构蛋白）、BimA（自转运蛋白）、BopA（III型分泌蛋白）和 嗜肺军团菌 LolC（ABC转运蛋白）进行免疫，可对致死性吸入 鼻疽伯克霍尔德菌 ATCC23344和 类鼻疽伯克霍尔德菌 1026b攻击产生显著保护作用。用BopA进行免疫引发的保护活性最强，分别使针对 鼻疽伯克霍尔德菌 和 类鼻疽伯克霍尔德菌 攻击的存活率达到100%和60%。此外，康复小鼠的血清与重组蛋白表现出反应性。用每种不同重组蛋白刺激的树突状细胞显示出不同的细胞因子模式。此外，免疫小鼠的T细胞在再次刺激后产生IFN-γ。因此，这些结果表明，用在 伯克霍尔德菌属 中鉴定出的一种或多种新型重组蛋白对动物进行疫苗接种，有可能引发针对 鼻疽伯克霍尔德菌 和 类鼻疽伯克霍尔德菌 的交叉保护性免疫。