Ratajczak Mariusz Z, Kim Chihwa
Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA ; Department of Physiology, Pomeranian Medical University, Poland.
Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA.
J Stem Cell Res Ther. 2011 Mar 30;1(2). doi: 10.4172/2157-7633.1000e102.
The α-chemokine stromal derived factor-1 (SDF-1) - seven transmembrane span receptor CXCR4 axis plays a crucial role in retention of hematopoietic stem progenitor cells (HSPCs) in BM. However, the mechanisms that govern mobilization/release of HSPCs from bone marrow (BM) into peripheral blood (PB) and direct a reverse process of their homing back into BM microenvironment after transplantation are still poorly understood. Augmenting evidence demonstrates that during both mobilization and myeloablative conditioning for transplantation a proteolytic microenvironment is induced in BM and complement cascade (CC) becomes activated. In this review we will present augmenting evidence that as result of induction of proteolytis microenvironment as well as CC activation bioactive sphingolipids - sphingosine - 1 phosphate (S1P) and ceramide-1-phosphate (C1P) together with CC cleavage fragments (C3a, C5a and C5b-C9) orchestrate both homing and mobilization of HSCPs.
α趋化因子基质衍生因子-1(SDF-1)-七跨膜受体CXCR4轴在造血干祖细胞(HSPCs)滞留于骨髓中起着关键作用。然而,关于HSPCs从骨髓(BM)动员/释放到外周血(PB)以及移植后指导其归巢回到骨髓微环境的反向过程的机制仍知之甚少。越来越多的证据表明,在移植的动员和清髓预处理过程中,骨髓中会诱导产生蛋白水解微环境,补体级联反应(CC)被激活。在本综述中,我们将展示越来越多的证据,即由于蛋白水解微环境的诱导以及CC的激活,生物活性鞘脂——鞘氨醇-1-磷酸(S1P)和神经酰胺-1-磷酸(C1P)与CC裂解片段(C3a、C5a和C5b-C9)共同协调HSCPs的归巢和动员。