在HELLP综合征大鼠模型中，高血压、炎症和T淋巴细胞均增加。
Hypertension, inflammation and T lymphocytes are increased in a rat model of HELLP syndrome.
作者信息
Wallace Kedra, Morris Rachael, Kyle Patrick B, Cornelius Denise, Darby Marie, Scott Jeremy, Moseley Janae, Chatman Krystal, Lamarca Babbette
机构信息
Department of Obstetrics & Gynecology .
出版信息
Hypertens Pregnancy. 2014 Feb;33(1):41-54. doi: 10.3109/10641955.2013.835820.
Abstract
OBJECTIVE
An animal model of hemolysis, elevated liver enzymes, low platelet count (HELLP) was used to determine if T lymphocytes accompany hypertension and increased inflammatory cytokines.
METHODS
sFlt-1 (4.7 µg/kg/day) and sEndoglin (7 µg/kg/day) were infused into normal pregnant rats (HELLP rats) for 8 days.
RESULTS
HELLP was associated with increased mean arterial pressure (p = 0.0001), hemolysis (p = 0.044), elevated liver enzymes (p = 0.027), and reduced platelets (p = 0.035). HELLP rats had increased plasma levels of TNFα (p = 0.039), IL-6 (p = 0.038) and IL-17 (p = 0.04). CD4(+) and CD8(+) T lymphocytes were increased.
CONCLUSION
These data support the hypothesis that T cells are associated with hypertension and inflammation.
摘要
目的
使用溶血、肝酶升高、血小板计数降低（HELLP）动物模型来确定T淋巴细胞是否与高血压及炎性细胞因子增加有关。
方法
将可溶性血管内皮生长因子受体-1（sFlt-1，4.7μg/kg/天）和可溶性内皮糖蛋白（sEndoglin，7μg/kg/天）注入正常妊娠大鼠（HELLP大鼠）体内，持续8天。
结果
HELLP与平均动脉压升高（p = 0.0001）、溶血（p = 0.044）、肝酶升高（p = 0.027）及血小板减少（p = 0.035）相关。HELLP大鼠血浆中肿瘤坏死因子α（TNFα，p = 0.039）、白细胞介素-6（IL-6，p = 0.038）和白细胞介素-17（IL-17，p = 0.04）水平升高。CD4(+)和CD8(+) T淋巴细胞增加。
结论
这些数据支持T细胞与高血压及炎症相关的假说。
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