Einhorn L H
Int J Androl. 1987 Feb;10(1):399-405. doi: 10.1111/j.1365-2605.1987.tb00210.x.
The treatment of testicular cancer has dramatically improved during the past decade. Combination chemotherapy with PVB was instituted at Indiana University in 1974. Subsequent studies demonstrated that: post PVB, surgery can cure patients; vinblastine dosage can be lowered from 0.4 to 0.3 mg/kg without sacrificing cure potential; maintenance vinblastine is not necessary; VP-16 can be substituted for vinblastine with equivalent cure rates and decreased neuromuscular toxicity.
在过去十年中，睾丸癌的治疗取得了显著进展。1974年，印第安纳大学开始采用顺铂、长春花碱和博来霉素联合化疗（PVB）。随后的研究表明：接受PVB化疗后，手术可治愈患者；长春花碱剂量可从0.4毫克/千克降至0.3毫克/千克，而不影响治愈可能性；无需维持使用长春花碱；用依托泊苷替代长春花碱可获得相同的治愈率，且神经肌肉毒性降低。
