Eroğlu A, Aydin F
Department of General Surgery & Surgical Oncology, Ankara University Medical School, Ankara 06260, Turkey.
Ankara University Medical School, Department of General Surgery, Ankara 06260, Turkey.
Exp Oncol. 2013 Dec;35(4):272-9.
In non-inflammatory locally advanced breast cancer, treatment typically includes neoadjuvant chemotherapy, surgery, and radiation therapy. Neoadjuvant chemotherapy allows in vivo assessment of primary tumor response to chemotherapy and is achieved the early control of micrometastatic disease. It also significantly improves surgical outcomes. Patients achieving pathologic complete response after neoadjuvant chemotherapy have a better survival. Tumor downsizing can make breast conserving therapy by -allowing for smaller resections and improving cosmesis. Tumor downstaging with chemotherapy can allow breast conserving surgery in patients who are initially candidate for mastectomy. Sentinel lymph node biopsy is an appropriate alternative to routine staging axillary dissection for early-stage breast cancer patients with clinically negative axillary nodes. During the last years there have been a number of clinical studies on effectiveness and role of sentinel lymph node biopsy in patients receiving neoadjuvant chemotherapy. The use of sentinel lymph node biopsy is an alternative approach to axillary dissection in patients with neoadjuvant therapy. In conclusion, patients with locally advanced breast cancer are treated with neoadjuvant chemotherapy followed by breast conserving surgery with axillary dissection and radiation therapy as a part of the multimodality management.
在非炎性局部晚期乳腺癌中，治疗通常包括新辅助化疗、手术和放射治疗。新辅助化疗可在体内评估原发性肿瘤对化疗的反应，并实现对微转移疾病的早期控制。它还能显著改善手术效果。新辅助化疗后达到病理完全缓解的患者生存率更高。肿瘤缩小可通过允许进行更小范围的切除并改善美观效果来实现保乳治疗。化疗使肿瘤降期可使原本适合乳房切除术的患者能够接受保乳手术。前哨淋巴结活检是临床腋窝淋巴结阴性的早期乳腺癌患者常规分期腋窝清扫术的合适替代方法。在过去几年中，有许多关于前哨淋巴结活检在接受新辅助化疗患者中的有效性和作用的临床研究。在前哨淋巴结活检的患者中，使用前哨淋巴结活检是腋窝清扫的替代方法。总之，局部晚期乳腺癌患者接受新辅助化疗，随后进行保乳手术并进行腋窝清扫和放射治疗，作为多模式治疗的一部分。
