Tennant C M, Seale J P, Temple D M
J Pharm Pharmacol. 1987 Apr;39(4):309-11. doi: 10.1111/j.2042-7158.1987.tb06274.x.
REV-5901, alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol, is an arylmethylphenyl ether derivative which inhibits 5-lipoxygenase activity of leukocytes. Its effects on the release of leukotrienes, induced by antigen and calcium ionophore, from human lung tissue in-vitro have been examined. At 1 and 10 microM it significantly inhibited the release of leukotrienes induced by both stimuli. At 10 microM it also inhibited antigen-induced histamine release. These results suggest that REV-5901 may be useful in clinical disorders such as asthma in which leukotriene release may be involved.
REV - 5901，α - 戊基 - 3 -（2 - 喹啉基甲氧基）苯甲醇，是一种芳基甲基苯基醚衍生物，可抑制白细胞的5 - 脂氧合酶活性。已研究了其对体外人肺组织中由抗原和钙离子载体诱导的白三烯释放的影响。在1和10微摩尔浓度时，它能显著抑制两种刺激物诱导的白三烯释放。在10微摩尔浓度时，它还能抑制抗原诱导的组胺释放。这些结果表明，REV - 5901可能对诸如哮喘等可能涉及白三烯释放的临床疾病有用。
