Kuki K, Fukuda Y, Maeda S, Yamada N, Asano G, Masugi Y, Oosono E, Yoshikawa A, Shimizu K, Shoji T
Gan No Rinsho. 1987 Mar;33(3):287-92.
We have reported a case of malignant lymphoma in associated with Hashimoto's disease arising in the right lobe of thyroid of a 57-year-old woman. The pre-operative aspirated biopsy was valuable for diagnosis Immuno-histochemical observations revealed the localization of anti B cell antibody in the cell surface of lymphoma cells and anti thyroglobulin antibody in intactly follicular epithelium within the lymphoma tissue. This lymphoma was diagnosed as diffuse, medium cell and B cell type. Radiation and chemotherapy were performed for multiple metastasis of liver and brain, but this case had died of DIC and diffuse hyaline membrane disease of lung.
我们报告了一例57岁女性右叶甲状腺出现的与桥本氏病相关的恶性淋巴瘤病例。术前细针穿刺活检对诊断有重要价值。免疫组织化学观察显示抗B细胞抗体定位于淋巴瘤细胞表面，抗甲状腺球蛋白抗体定位于淋巴瘤组织内完整的滤泡上皮细胞。该淋巴瘤被诊断为弥漫性、中等细胞性和B细胞型。针对肝和脑的多处转移进行了放疗和化疗，但该病例死于弥散性血管内凝血和肺透明膜病。
