胰腺癌治疗的挑战与工程间充质干细胞的新型治疗策略。
The challenge of pancreatic cancer therapy and novel treatment strategy using engineered mesenchymal stem cells.
机构信息
Department of Surgery, University of British Columbia, Vancouver BC, Canada.
1] Department of Surgery, University of British Columbia, Vancouver BC, Canada [2] Hubei Key Laboratory of Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
出版信息
Cancer Gene Ther. 2014 Jan;21(1):12-23. doi: 10.1038/cgt.2013.83. Epub 2014 Jan 3.
Mesenchymal stem cells (MSCs) have attracted significant attention in cancer research as a result of their accessibility, tumor-oriented homing capacity, and the feasibility of auto-transplantation. This review provides a comprehensive overview of current challenges in pancreatic cancer therapy, and we propose a novel strategy for using MSCs as means of delivering anticancer genes to the site of pancreas. We aim to provide a practical platform for the development of MSC-based therapy for pancreatic cancer.
间充质干细胞（MSCs）因其易于获取、肿瘤趋向性归巢能力以及自体移植的可行性，在癌症研究中引起了广泛关注。本综述全面概述了当前胰腺癌治疗所面临的挑战，并提出了一种利用 MSCs 将抗癌基因递送到胰腺部位的新策略。我们旨在为基于 MSC 的胰腺癌治疗的发展提供一个实用的平台。
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