暴饮暴食症中IGF-II亚型的特征及其团体心理治疗
Characterization of IGF-II isoforms in binge eating disorder and its group psychological treatment.
作者信息
Tasca Giorgio, Lelievre Julien Yockell, Qiu Qing, Ritchie Kerri, Little Julian, Trinneer Anne, Barber Ann, Chyurlia Livia, Bissada Hany, Gruslin Andreé
机构信息
Psychology Department, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada ; Department of Psychiatry, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Department of Cellular and Molecular Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada ; Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada.
出版信息
PLoS One. 2013 Dec 30;8(12):e83019. doi: 10.1371/journal.pone.0083019. eCollection 2013.
INTRO
Binge eating disorder (BED) affects 3.5% of the population and is characterized by binge eating for at least 2 days a week for 6 months. Treatment options include cognitive behavioral therapy, interpersonal psychotherapy, and pharmacotherapy which are associated with varied success. Little is known about the biology of BED. Since there is evidence that the insulin like growth factor system is implicated in regulation of body weight, insulin sensitivity and feeding behavior, we speculated it may be involved in BED.
METHODS
A cross-sectional comparison was made between three groups of women: overweight with BED, overweight without BED and normal weight without BED. Women were assigned to Group Psychodynamic Interpersonal Psychotherapy. Blood was collected before therapy, at completion and at 6 months follow up for evaluation of IGF-II using Western blot.
RESULTS
97 overweight women with BED contributed to the cross-sectional comparison. The two control groups comprised 53 overweight women without BED, and 50 age matched normal weight women without BED. Obese women had significantly lower Big IGF-II than normal weight women, p = .028; Overweight women with BED had higher Mature IGF-II than normal weight women, p<.05. Big IGF-II showed a significant decreasing slope from pre- to post- to six months post-group psychological treatment, unrelated to changes in BMI (p = .008).
CONCLUSION
Levels of IGF-II isoforms differed significantly between overweight and normal weight women. Overweight women with BED display abnormal levels of circulating IGF-II isoforms. BED is characterized by elevated mature IGF-II, an isoform shown to carry significant bioactivity. This finding is not related to BMI or to changes in body weight. The results also provide preliminary evidence that BIG IGF-II is sensitive to change due to group psychological treatment. We suggest that abnormalities in IGF-II processing may be involved in the neurobiology of BED.
引言
暴饮暴食症（BED）影响着3.5%的人口，其特征是每周至少有2天暴饮暴食，持续6个月。治疗选择包括认知行为疗法、人际心理疗法和药物疗法，这些疗法的成功率各不相同。人们对暴饮暴食症的生物学机制知之甚少。由于有证据表明胰岛素样生长因子系统与体重调节、胰岛素敏感性和进食行为有关，我们推测它可能与暴饮暴食症有关。
方法
对三组女性进行横断面比较：患有暴饮暴食症的超重女性、未患暴饮暴食症的超重女性和体重正常且未患暴饮暴食症的女性。将女性分配到心理动力人际心理治疗组。在治疗前、治疗结束时和随访6个月时采集血液，使用蛋白质免疫印迹法评估IGF-II。
结果
97名患有暴饮暴食症的超重女性参与了横断面比较。两个对照组包括53名未患暴饮暴食症的超重女性和50名年龄匹配的体重正常且未患暴饮暴食症的女性。肥胖女性的大IGF-II明显低于体重正常的女性，p = 0.028；患有暴饮暴食症的超重女性的成熟IGF-II高于体重正常的女性，p<0.05。从治疗前到治疗后再到治疗后6个月，大IGF-II呈现出显著下降的趋势，这与体重指数的变化无关（p = 0.008）。
结论
超重和体重正常的女性之间IGF-II亚型的水平存在显著差异。患有暴饮暴食症的超重女性循环IGF-II亚型水平异常。暴饮暴食症的特征是成熟IGF-II升高，该亚型具有显著的生物活性。这一发现与体重指数或体重变化无关。研究结果还提供了初步证据，表明大IGF-II对团体心理治疗引起的变化敏感。我们认为IGF-II加工异常可能参与了暴饮暴食症的神经生物学机制。
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