Department of Chemical Engineering and Institute of Biomedical Engineering, National Tsing Hua University , Hsinchu 30013, Taiwan (ROC).
ACS Nano. 2014 Feb 25;8(2):1213-21. doi: 10.1021/nn4058787. Epub 2014 Jan 13.
Oxidative stress and reduced pH are involved in many inflammatory diseases. This study describes a nanoparticle-based system that is responsive to both oxidative stress and reduced pH in an inflammatory environment to effectively release its encapsulated curcumin, an immune-modulatory agent with potent anti-inflammatory and antioxidant capabilities. Because of the presence of Förster resonance energy transfer between curcumin and the carrier, this system also allowed us to monitor the intracellular release behavior. The curcumin released upon triggering could efficiently reduce the excess oxidants produced by the lipopolysaccharide (LPS)-stimulated macrophages. The feasibility of using the curcumin-loaded nanoparticles for anti-inflammatory applications was further validated in a mouse model with ankle inflammation induced by LPS. The results of these studies demonstrate that the proposed nanoparticle system is promising for treating oxidative stress-related diseases.
氧化应激和 pH 值降低与许多炎症性疾病有关。本研究描述了一种基于纳米粒子的系统，该系统可响应炎症环境中的氧化应激和 pH 值降低，从而有效释放其包封的姜黄素，姜黄素是一种具有强大抗炎和抗氧化能力的免疫调节剂。由于姜黄素和载体之间存在Förster 共振能量转移，因此该系统还使我们能够监测细胞内的释放行为。触发后释放的姜黄素可以有效地减少脂多糖 (LPS) 刺激的巨噬细胞产生的多余氧化剂。用载有姜黄素的纳米粒子进行抗炎应用的可行性在 LPS 诱导的踝关节炎症的小鼠模型中得到了进一步验证。这些研究的结果表明，所提出的纳米粒子系统在治疗与氧化应激相关的疾病方面具有广阔的应用前景。
