HEPES缓冲液对氯离子通道的阻断作用。
Blockage of chloride channels by HEPES buffer.
作者信息
Yamamoto D, Suzuki N
出版信息
Proc R Soc Lond B Biol Sci. 1987 Feb 23;230(1258):93-100. doi: 10.1098/rspb.1987.0011.
PMID:2438701
Abstract
Chloride channels of neurons of Drosophila are blocked when the cytoplasmic side of the membrane is exposed to the commonly used buffering agents 4-(2-hydroxyethyl)-1-piperazine ethanesulphonic acid (HEPES) and 4-morpholinepropanesulphonic acid (MOPS). In the presence of these compounds, chloride channels appear to function as a complex of multiple protochannels.
摘要
当果蝇神经元细胞膜的胞质侧暴露于常用缓冲剂4-(2-羟乙基)-1-哌嗪乙磺酸（HEPES）和4-吗啉丙磺酸（MOPS）时，其氯离子通道会被阻断。在这些化合物存在的情况下，氯离子通道似乎以多个原通道的复合物形式发挥作用。
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