Área de Toxicología, Departamento de Fisiopatología - Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro, Campus Universitario, Paraje Arroyo Seco s/n, Tandil, Argentina.
Área de Producción Porcina, Departamento de Producción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro, Campus Universitario, Paraje Arroyo Seco s/n, Tandil, Argentina.
Res Vet Sci. 2014 Feb;96(1):153-9. doi: 10.1016/j.rvsc.2013.12.003. Epub 2013 Dec 12.
The objective of this study was to document the effect of social ranking on the internal exposure of pigs to an antibiotic (fosfomycin) administered either in food or in drinking water. Signs of aggression were recorded at the feeder and drinker. The interindividual variability explained by the social rank was even greater when the test antibiotic was given in food despite the fact that the water consumption was less variable than the food intake. The range of plasma concentrations after administration of fosfomycin either in food or drinking water leads to a number of pigs in the treated group being exposed to rather low and highly variable concentrations of fosfomycin and not able to maintain adequate plasma concentrations above the typical minimum inhibitory concentration (MIC). Social rank clearly influences the level of exposure of pigs to fosfomycin both in food and drinking. However, its administration in drinking water is likely to be the best option to optimize antibiotic efficacy.
本研究旨在记录社会等级对猪通过饲料或饮水摄入抗生素（磷霉素）的体内暴露的影响。在饲料器和饮水器处记录了攻击迹象。尽管水的摄入量比食物的摄入量变化小，但当测试抗生素通过饲料给予时，个体间的差异由社会等级解释的程度更大。在给与饲料或饮水给予磷霉素后，血浆浓度的范围导致处理组中的一些猪接触到相当低且高度可变的磷霉素浓度，并且无法维持高于典型最小抑菌浓度（MIC）的足够的血浆浓度。社会等级显然会影响猪通过饲料和饮水摄入磷霉素的暴露水平。然而，通过饮水给予磷霉素可能是优化抗生素疗效的最佳选择。
