Sindrup J H, Avnstorp C, Steenfos H H, Kristensen J K
Acta Derm Venereol. 1987;67(2):160-3.
The study included 40 patients with clinically venous leg ulcer(s) in one leg only and with a systolic toe blood pressure above 50 mmHg in both legs. Transcutaneous oxygen tension was measured on both lower legs at equivalent sites, on the affected leg immediately proximal to the ulcer(s). Similarly, skin blood flow was measured in both legs at a skin temperature of 32 degrees C and 44 degrees C by means of laser Doppler velocimetry, and for each leg the index of blood flow 44 degrees C/flow 32 degrees C was calculated to express the degree of blood flow increment following local hyperthermia. Transcutaneous oxygen tension measurements were significantly lower on affected legs (p less than 0.01) as was flow increment (p less than 0.01), mainly due to a high flow measurement at 32 degrees C on affected legs rather than to a low measurement at 44 degrees C. The results of our flow measurements suggest a state of (relative) hyperemia in the vicinity of venous leg ulcers, also confirmed by the clinical findings. This could be interpreted as an arteriolar response to lowered oxygen tension or (it could) be part of reactive reparative processes leading to increased O2 consumption in the tissues.
该研究纳入了40例仅一侧腿部患有临床诊断的静脉性腿部溃疡且双腿趾收缩压均高于50 mmHg的患者。在双腿相同部位测量经皮氧分压，在患侧溃疡近端紧邻处测量。同样，通过激光多普勒测速仪在双腿皮肤温度为32℃和44℃时测量皮肤血流，并计算每条腿的血流指数（44℃时的血流/32℃时的血流）以表示局部热疗后血流增加的程度。患侧腿部的经皮氧分压测量值显著更低（p<0.01），血流增加量也是如此（p<0.01），主要是因为患侧腿部在32℃时的血流测量值较高，而非44℃时的测量值较低。我们的血流测量结果提示静脉性腿部溃疡附近存在（相对）充血状态，临床发现也证实了这一点。这可以解释为小动脉对氧分压降低的反应，或者（它可能）是导致组织中氧消耗增加的反应性修复过程的一部分。
