Department of Food and Nutrition, Korea University, Seoul 136-703, Republic of Korea.
Department of Applied Bioscience, CHA University, Gyeonggi-do 463-836, Republic of Korea.
Biochem Biophys Res Commun. 2014 Jan 17;443(3):1110-7. doi: 10.1016/j.bbrc.2013.12.120. Epub 2014 Jan 2.
We tested whether long-term administration of voglibose (VO) prevents diet induced obesity in addition to hypoglycemic effects in high fat fed mice and further investigated the underlying mechanisms by which voglibose exerts its weight lowering effect. Male C57BL/6 mice were fed ad libitum for 12 weeks with the control diet (CTL), high-fat diet (HFD) or the HFD with VO supplementations. Blood lipid profile, plasma leptin levels and hepatic triglyceride content, as well as expressions of genes involved in appetite and mitochondrial function were examined. The results showed that VO significantly reduced body weight, fat mass and energy intakes in high fat fed mice. VO showed improved metabolic profiles including blood glucose, triglyceride and free fatty acid. Elevated levels of plasma leptin in HFD were significantly reduced with the VO, furthermore, VO modulated the hypothalamic expressions of leptin receptors and appetite related genes. VO showed the upregulated expressions of PGC-1 in the liver and epididymal adipose tissue. In conclusion, VO may exert antiobesity properties through reductions in energy intake and improvement in mitochondrial function, indicating that VO has potential therapeutic use in patients with obesity, type 2 diabetes, and related complications.
我们测试了长期给予伏格列波糖（VO）是否除了具有降血糖作用外，还可以预防高脂肪饮食诱导的肥胖，并进一步研究了伏格列波糖发挥其降低体重作用的潜在机制。雄性 C57BL/6 小鼠自由进食 12 周，分别给予对照饮食（CTL）、高脂肪饮食（HFD）或 HFD 加 VO 补充。检测血脂谱、血浆瘦素水平和肝甘油三酯含量，以及参与食欲和线粒体功能的基因表达。结果表明，VO 可显著降低高脂肪饮食喂养小鼠的体重、脂肪量和能量摄入。VO 改善了代谢谱，包括血糖、甘油三酯和游离脂肪酸。HFD 中升高的血浆瘦素水平随 VO 而显著降低，此外，VO 调节了下丘脑瘦素受体和食欲相关基因的表达。VO 显示肝脏和附睾脂肪组织中 PGC-1 的表达上调。总之，VO 通过减少能量摄入和改善线粒体功能发挥抗肥胖作用，表明 VO 对肥胖、2 型糖尿病及相关并发症患者具有潜在的治疗用途。
