Boron neutron capture therapy as new treatment for clear cell sarcoma: trial on different animal model.
作者信息
Andoh Tooru, Fujimoto Takuya, Sudo Tamotsu, Suzuki Minoru, Sakurai Yoshinori, Sakuma Toshiko, Moritake Hiroshi, Sugimoto Tohru, Takeuchi Tamotsu, Sonobe Hiroshi, Epstein Alan L, Fukumori Yoshinobu, Ono Koji, Ichikawa Hideki
机构信息
Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-8558, Japan.
出版信息
Appl Radiat Isot. 2014 Jun;88:59-63. doi: 10.1016/j.apradiso.2013.12.007. Epub 2013 Dec 17.
Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In our previous study, the tumor disappeared under boron neutron capture therapy (BNCT) on subcutaneously-transplanted CCS-bearing animals. In the present study, the tumor disappeared under this therapy on model mice intramuscularly implanted with three different human CCS cells. BNCT led to the suppression of tumor-growth in each of the different model mice, suggesting its potentiality as an alternative to, or integrative option for, the treatment of CCS.
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