白细胞介素-6阻断剂在风湿性疾病中的临床经验——对白细胞介素-6生物学及疾病发病机制的影响
Clinical experience of IL-6 blockade in rheumatic diseases - implications on IL-6 biology and disease pathogenesis.
作者信息
Davies Ruth, Choy Ernest
机构信息
CREATE Centre, Section of Rheumatology, Institute of Infection and Immunity, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
CREATE Centre, Section of Rheumatology, Institute of Infection and Immunity, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
出版信息
Semin Immunol. 2014 Feb;26(1):97-104. doi: 10.1016/j.smim.2013.12.002. Epub 2014 Jan 2.
Interleukin 6 (IL-6) plays a significant role in many rheumatological diseases and has been described as both a pro- and anti-inflammatory cytokine. IL-6 blockade has been investigated in various rheumatic diseases and a humanised anti-IL-6 receptor antibody has been licensed for use in rheumatoid arthritis, systemic and polyarticular juvenile idiopathic arthritis. The increasing clinical experience of IL-6 blockade in rheumatic diseases adds to the existing knowledge regarding the physiological and pathological roles of IL-6.
白细胞介素6（IL-6）在许多风湿性疾病中发挥着重要作用，被描述为一种促炎和抗炎细胞因子。在各种风湿性疾病中都对IL-6阻断进行了研究，一种人源化抗IL-6受体抗体已被批准用于类风湿性关节炎、全身性和多关节幼年特发性关节炎。在风湿性疾病中IL-6阻断的临床经验不断增加，这丰富了关于IL-6生理和病理作用的现有知识。
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